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MeSH Review


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Disease relevance of Conjunctiva


High impact information on Conjunctiva

  • We assessed symptom score by diary cards and inflammatory-cell infiltrate, and expression of intercellular adhesion molecule 1 (ICAM-1) in the conjunctiva after specific allergen challenge at enrollment and after 12 and 24 months of treatment [6].
  • In order to identify gonococcal factors essential for invading Chang human conjunctiva cells, a gentamicin selection assay for the quantification of viable intracellular bacteria was used in conjunction with microscopy [7].
  • The sera recognized a 205-kDa protein in human epidermal, human conjunctiva, and tumor cell lysates that was identified as beta 4-integrin by its reaction with polyclonal and monoclonal antibodies to human beta 4-integrin [8].
  • Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva [9].
  • Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs.(ABSTRACT TRUNCATED AT 250 WORDS)[10]

Chemical compound and disease context of Conjunctiva


Biological context of Conjunctiva


Anatomical context of Conjunctiva


Associations of Conjunctiva with chemical compounds

  • Extravasated 125I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg [10].
  • Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva [10].
  • The tear clearance rate is measured by fluorescein dye dilution in the conjunctiva [26].
  • Three adult patients with Bitot's spots of the conjunctiva were observed in the American Southwest; all were in good health without obvious cause for vitamin A deficiency [27].
  • These results indicate that following cyclooxygenase inhibition by indomethacin rabbit conjunctiva and anterior uvea generate SRS-like activity from arachidonic acid via lipoxygenase pathways [28].

Gene context of Conjunctiva


Analytical, diagnostic and therapeutic context of Conjunctiva


  1. Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. Miyazaki, D., Nakamura, T., Toda, M., Cheung-Chau, K.W., Richardson, R.M., Ono, S.J. J. Clin. Invest. (2005) [Pubmed]
  2. Alteration of sialyl Lewis epitope expression in pterygium. Creuzot-Garcher, C., Guerzider, V., Assem, M., Bron, A.M., Delannoy, P., Bara, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  3. Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. Lambiase, A., Bonini, S., Bonini, S., Micera, A., Magrini, L., Bracci-Laudiero, L., Aloe, L. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  4. Epidermodysplasia verruciformis human papillomavirus types and carcinoma of the conjunctiva: a pilot study. Ateenyi-Agaba, C., Weiderpass, E., Smet, A., Dong, W., Dai, M., Kahwa, B., Wabinga, H., Katongole-Mbidde, E., Franceschi, S., Tommasino, M. Br. J. Cancer (2004) [Pubmed]
  5. Physiologic indicators of vitamin A status. Congdon, N.G., West, K.P. J. Nutr. (2002) [Pubmed]
  6. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Passalacqua, G., Albano, M., Fregonese, L., Riccio, A., Pronzato, C., Mela, G.S., Canonica, G.W. Lancet (1998) [Pubmed]
  7. Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells. Makino, S., van Putten, J.P., Meyer, T.F. EMBO J. (1991) [Pubmed]
  8. Ocular cicatricial pemphigoid antigen: partial sequence and biochemical characterization. Tyagi, S., Bhol, K., Natarajan, K., Livir-Rallatos, C., Foster, C.S., Ahmed, A.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva. Kirveskari, J., Helintö, M., Moilanen, J.A., Paavonen, T., Tervo, T.M., Renkonen, R. Blood (2002) [Pubmed]
  10. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. Markowitz, S., Saito, K., Moskowitz, M.A. J. Neurosci. (1987) [Pubmed]
  11. Hyperexpression of low-density lipoprotein receptors and hydroxy-methylglutaryl-coenzyme A-reductase in human pinguecula and primary pterygium. Peiretti, E., Dessì, S., Putzolu, M., Fossarello, M. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  12. Treatment of ocular adnexal Kaposi's sarcoma in acquired immune deficiency syndrome. Dugel, P.U., Gill, P.S., Frangieh, G.T., Rao, N.A. Ophthalmology (1992) [Pubmed]
  13. Oxygen transport and utilization in hyperoxia and hypoxia: relation of conjunctival and transcutaneous oxygen tensions to hemodynamic and oxygen transport variables. Fink, S., Ray, C.W., McCartney, S., Ehrlich, H., Shoemaker, W.C. Crit. Care Med. (1984) [Pubmed]
  14. Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. Nakahara, H., Izushi, K., Sugimoto, Y., Watanabe, T., Kamei, C. Eur. J. Pharmacol. (2000) [Pubmed]
  15. Bacterial contamination of the anterior chamber during phacoemulsification cataract surgery. Leong, J.K., Shah, R., McCluskey, P.J., Benn, R.A., Taylor, R.F. Journal of cataract and refractive surgery. (2002) [Pubmed]
  16. Immunomorphologic studies of mast cell heterogeneity, location, and distribution in the rat conjunctiva. McMenamin, P.G., Morrison, S.M., McMenamin, C. J. Allergy Clin. Immunol. (1996) [Pubmed]
  17. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Kammandel, B., Chowdhury, K., Stoykova, A., Aparicio, S., Brenner, S., Gruss, P. Dev. Biol. (1999) [Pubmed]
  18. The effect of platelet-activating factor (PAF), histamine, and ethanol on vascular permeability of the guinea pig conjunctiva. Stock, E.L., Roth, S.I., Kim, E.D., Walsh, M.K., Thamman, R. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  19. Specialized protective role of mucosal glutathione in pigmented rabbit conjunctiva. Gukasyan, H.J., Kim, K.J., Kannan, R., Farley, R.A., Lee, V.H. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  20. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Gipson, I.K., Spurr-Michaud, S., Argüeso, P., Tisdale, A., Ng, T.F., Russo, C.L. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  21. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. Fukushima, A., Yamaguchi, T., Ishida, W., Fukata, K., Mittler, R.S., Yagita, H., Ueno, H. J. Immunol. (2005) [Pubmed]
  22. A novel interaction between type IV pili of Neisseria gonorrhoeae and the human complement regulator C4B-binding protein. Blom, A.M., Rytkönen, A., Vasquez, P., Lindahl, G., Dahlbäck, B., Jonsson, A.B. J. Immunol. (2001) [Pubmed]
  23. High expression levels of the "erythroid/brain" type glucose transporter (GLUT1) in the basal cells of human eye conjunctiva and oral mucosa reconstituted in culture. Gherzi, R., Melioli, G., De Luca, M., D'Agostino, A., Guastella, M., Traverso, C.E., D'Anna, F., Franzi, A.T., Cancedda, R. Exp. Cell Res. (1991) [Pubmed]
  24. M cells in the follicle-associated epithelium of the rabbit conjunctiva preferentially bind and translocate latex beads. Liu, H., Meagher, C.K., Moore, C.P., Phillips, T.E. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  25. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera. Hämäläinen, K.M., Kananen, K., Auriola, S., Kontturi, K., Urtti, A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  26. Tear dynamics and dry eye. Tsubota, K. Progress in retinal and eye research. (1998) [Pubmed]
  27. Clinical and electron microscopic observations of the conjunctiva of adult patients with Bitot's spots. Ganley, J.P., Payne, C.M. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]
  28. Synthesis of slow reacting substance-like activity in rabbit conjunctiva and anterior uvea. Kulkarni, P.S., Srinivason, B.D. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  29. Human corneal and conjunctival epithelia express MUC1 mucin. Inatomi, T., Spurr-Michaud, S., Tisdale, A.S., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  30. Quantification of MUC2 and MUC5AC transcripts in human conjunctiva. McKenzie, R.W., Jumblatt, J.E., Jumblatt, M.M. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  31. Costimulatory molecules in ocular cicatricial pemphigoid. Tesavibul, N., Dorfman, D., Sangwan, V.S., Christen, W., Panayotis, Z., Rojas, B., Foster, C.S. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  32. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Razzaque, M.S., Foster, C.S., Ahmed, A.R. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  33. Expression of secretory mucin genes by human conjunctival epithelia. Inatomi, T., Spurr-Michaud, S., Tisdale, A.S., Zhan, Q., Feldman, S.T., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  34. Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice. Ueta, M., Hamuro, J., Yamamoto, M., Kaseda, K., Akira, S., Kinoshita, S. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  35. Iontophoresis of 5-fluorouracil into the conjunctiva and sclera. Kondo, M., Araie, M. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  36. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Diebold, Y., Ríos, J.D., Hodges, R.R., Rawe, I., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  37. Unusual structure of rat conjunctival epithelium. Light and electron microscopy. Setzer, P.Y., Nichols, B.A., Dawson, C.R. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
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