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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.

Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.[1]

References

  1. Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways. Wiederhold, N.P., Kontoyiannis, D.P., Prince, R.A., Lewis, R.E. Antimicrob. Agents Chemother. (2005) [Pubmed]
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