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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.

The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.[1]

References

  1. Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate. Matsue, H., Rothberg, K.G., Takashima, A., Kamen, B.A., Anderson, R.G., Lacey, S.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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