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Chemical Compound Review

Extrafolate-S     (2R)-2-[[4-[(2-amino-5- methyl-4-oxo-1,6,7...

Synonyms: L-methylfolate, Methyl folate, HMDB01396, AC1L96XW, 134-35-0, ...
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Disease relevance of C00440


Psychiatry related information on C00440


High impact information on C00440


Chemical compound and disease context of C00440


Biological context of C00440


Anatomical context of C00440


Associations of C00440 with other chemical compounds


Gene context of C00440


Analytical, diagnostic and therapeutic context of C00440


  1. Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Camilo, E., Zimmerman, J., Mason, J.B., Golner, B., Russell, R., Selhub, J., Rosenberg, I.H. Gastroenterology (1996) [Pubmed]
  2. 5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia. Kano, Y., Sakamoto, S., Hida, K., Suda, K., Takaku, F. Blood (1982) [Pubmed]
  3. Transport and utilization of methyltetrahydrofolates by Lactobacillus casei. Shane, B., Stokstad, E.L. J. Biol. Chem. (1976) [Pubmed]
  4. Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. Clark, J.E., Ljungdahl, L.G. J. Biol. Chem. (1984) [Pubmed]
  5. Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major roles in folate binding and catalysis and a minor role in flavin reactivity. Trimmer, E.E., Ballou, D.P., Galloway, L.J., Scannell, S.A., Brinker, D.R., Casas, K.R. Biochemistry (2005) [Pubmed]
  6. Spinal fluid 5-methyltetrahydrofolate levels are normal in Rett syndrome. Neul, J.L., Maricich, S.M., Islam, M., Barrish, J., Smith, E.O., Bottiglieri, T., Hyland, K., Humphreys, P., Percy, A., Glaze, D. Neurology (2005) [Pubmed]
  7. The effect of tetrahydrofolate on tetrahydrobiopterin metabolism. Hamon, C.G., Blair, J.A., Barford, P.A. Journal of mental deficiency research. (1986) [Pubmed]
  8. Level of methionine synthase activity and interconversion of methylcobalamin and adenosylcobalamin in a facultative methylotroph, Protaminobacter ruber. Sato, K., Shimizu, S. J. Nutr. Sci. Vitaminol. (1980) [Pubmed]
  9. Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Moretti, P., Sahoo, T., Hyland, K., Bottiglieri, T., Peters, S., del Gaudio, D., Roa, B., Curry, S., Zhu, H., Finnell, R.H., Neul, J.L., Ramaekers, V.T., Blau, N., Bacino, C.A., Miller, G., Scaglia, F. Neurology (2005) [Pubmed]
  10. Caveolin, a protein component of caveolae membrane coats. Rothberg, K.G., Heuser, J.E., Donzell, W.C., Ying, Y.S., Glenney, J.R., Anderson, R.G. Cell (1992) [Pubmed]
  11. Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation. Kamen, B.A., Johnson, C.A., Wang, M.T., Anderson, R.G. J. Clin. Invest. (1989) [Pubmed]
  12. Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells. Kane, M.A., Elwood, P.C., Portillo, R.M., Antony, A.C., Najfeld, V., Finley, A., Waxman, S., Kolhouse, J.F. J. Clin. Invest. (1988) [Pubmed]
  13. The mechanism of 5-methyltetrahydrofolate transport by human erythrocytes. Branda, R.F., Anthony, B.K., Jacob, H.S. J. Clin. Invest. (1978) [Pubmed]
  14. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Surtees, R., Leonard, J., Austin, S. Lancet (1991) [Pubmed]
  15. Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture. Refsum, H., Christensen, B., Djurhuus, R., Ueland, P.M. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  16. The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy. Blanco, J., Coque, J.J., Martin, J.F. J. Bacteriol. (1998) [Pubmed]
  17. 5-Fluorouracil plus 5-methyltetrahydrofolate in advanced pancreatic cancer. GLISP (Gruppo Ligure Studio Pancreas). Bolli, E., Saccomanno, S., Mondini, G., Aschele, C., Guglielmi, A., Ligas, B., Connio, M., Mori, A., Rosso, R., Sobrero, A. Cancer Chemother. Pharmacol. (1995) [Pubmed]
  18. Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia. Aplenc, R., Thompson, J., Han, P., La, M., Zhao, H., Lange, B., Rebbeck, T. Cancer Res. (2005) [Pubmed]
  19. 5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines. Pizzorno, G., Cashmore, A.R., Moroson, B.A., Cross, A.D., Smith, A.K., Marling-Cason, M., Kamen, B.A., Beardsley, G.P. J. Biol. Chem. (1993) [Pubmed]
  20. The impaired renal vasodilator response attributed to endothelium-derived hyperpolarizing factor in streptozotocin--induced diabetic rats is restored by 5-methyltetrahydrofolate. De Vriese, A.S., Van de Voorde, J., Blom, H.J., Vanhoutte, P.M., Verbeke, M., Lameire, N.H. Diabetologia (2000) [Pubmed]
  21. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Melse-Boonstra, A., Verhoef, P., West, C.E., van Rhijn, J.A., van Breemen, R.B., Lasaroms, J.J., Garbis, S.D., Katan, M.B., Kok, F.J. Am. J. Clin. Nutr. (2006) [Pubmed]
  22. Effect of food on the oral bioavailability of UFT and leucovorin in cancer patients. Damle, B., Ravandi, F., Kaul, S., Sonnichsen, D., Ferreira, I., Brooks, D., Stewart, D., Alberts, D., Pazdur, R. Clin. Cancer Res. (2001) [Pubmed]
  23. Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells. Smart, E.J., Mineo, C., Anderson, R.G. J. Cell Biol. (1996) [Pubmed]
  24. Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate. Matsue, H., Rothberg, K.G., Takashima, A., Kamen, B.A., Anderson, R.G., Lacey, S.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  25. Hereditary dyserythropoiesis with abnormal membrane folate transport. Howe, R.B., Branda, R.F., Douglas, S.D., Brunning, R.D. Blood (1979) [Pubmed]
  26. Receptor-mediated folate uptake is positively regulated by disruption of the actin cytoskeleton. Lewis, C.M., Smith, A.K., Kamen, B.A. Cancer Res. (1998) [Pubmed]
  27. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Jacques, P.F., Bostom, A.G., Williams, R.R., Ellison, R.C., Eckfeldt, J.H., Rosenberg, I.H., Selhub, J., Rozen, R. Circulation (1996) [Pubmed]
  28. Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies. Surtees, R., Clelland, J., Hann, I. J. Clin. Oncol. (1998) [Pubmed]
  29. Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates. Houghton, P.J., Rahman, A., Will, C.L., Dolnick, B.J., Houghton, J.A. Cancer Res. (1992) [Pubmed]
  30. Effects of nitrous oxide on human cell lines. Kano, Y., Sakamoto, S., Sakuraya, K., Kubota, T., Kasahara, T., Hida, K., Suda, K., Takaku, F. Cancer Res. (1983) [Pubmed]
  31. Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates. Matherly, L.H., Anderson, L.A., Goldman, I.D. Cancer Res. (1984) [Pubmed]
  32. Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae. Shan, X., Wang, L., Hoffmaster, R., Kruger, W.D. J. Biol. Chem. (1999) [Pubmed]
  33. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. D'Angelo, A., Coppola, A., Madonna, P., Fermo, I., Pagano, A., Mazzola, G., Galli, L., Cerbone, A.M. Thromb. Haemost. (2000) [Pubmed]
  34. Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Yeo, E.J., Wagner, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  35. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. Zhao, R., Russell, R.G., Wang, Y., Liu, L., Gao, F., Kneitz, B., Edelmann, W., Goldman, I.D. J. Biol. Chem. (2001) [Pubmed]
  36. Molecular cloning of the human placental folate transporter. Prasad, P.D., Ramamoorthy, S., Leibach, F.H., Ganapathy, V. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  37. l-folinic acid versus d,l-folinic acid in rescue of high-dose methotrexate therapy in children. Etienne, M.C., Thyss, A., Bertrand, Y., Touraine, R., Rubie, H., Robert, A., Milano, G. J. Natl. Cancer Inst. (1992) [Pubmed]
  38. Accumulation of 5-methyltetrahydrofolate in cobalamin-deficient L1210 mouse leukemia cells. Fujii, K., Nagasaki, T., Huennekens, F.M. J. Biol. Chem. (1982) [Pubmed]
  39. 5,10-Methylenetetrahydrofolate reductase (MTHFR) assay in the forward direction: residual activity in MTHFR deficiency. Suormala, T., Gamse, G., Fowler, B. Clin. Chem. (2002) [Pubmed]
  40. Retained folates in the rat. Barford, P.A., Staff, R.J., Blair, J.A. Biochem. J. (1977) [Pubmed]
  41. Immunoassay of 5-methyltetrahydrofolate: use of 125I-labeled protein A as the tracer molecule for specific antibody. Langone, J.J. Anal. Biochem. (1980) [Pubmed]
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