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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Angiotensin-converting enzyme genotype and adherence to aerobic exercise training.

Angiotensin-converting enzyme (ACE) has two common genetic variants: the insertion (I) and deletion (D) forms. ACE levels are greater in subjects with the D allele, and several studies suggest superior endurance performance in subjects with the I allele. The authors recently reported the results of a 6-month exercise training protocol examining the effect of apolipoprotein E on the lipid response. The present report examines the relationship of ACE genotype and exercise adherence. DNA samples were available for 110 subjects: 14 I/I, 52 I/D, and 44 D/D. Baseline and change in maximal oxygen uptake, body mass index, skinfold thickness, and serum lipids did not differ by ACE genotype, but adherence to exercise training was higher in I carriers than in D homozygotes. These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen.[1]


  1. Angiotensin-converting enzyme genotype and adherence to aerobic exercise training. Thompson, P.D., Tsongalis, G.J., Ordovas, J.M., Seip, R.L., Bilbie, C., Miles, M., Zoeller, R., Visich, P., Gordon, P., Angelopoulos, T.J., Pescatello, L., Moyna, N. Preventive cardiology. (2006) [Pubmed]
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