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MeSH Review

Body Mass Index

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Disease relevance of Body Mass Index


Psychiatry related information on Body Mass Index


High impact information on Body Mass Index


Chemical compound and disease context of Body Mass Index


Biological context of Body Mass Index


Anatomical context of Body Mass Index


Associations of Body Mass Index with chemical compounds

  • Body mass index, cholesterol level, electrocardiogram, race, prior cardiovascular disease, smoking status, initial and final revisit BP, total intreatment BP, and systolic BP were not [30].
  • The significant case-control difference in LDL size was independent of levels of high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C), triglyceride, smoking, systolic blood pressure, and body mass index, but was not significant after adjusting for the ratio of total cholesterol (TC) to HDL-C (TC:HDL-C) [31].
  • These associations were independent of age, body mass index, smoking status, and use of thiazides, corticosteroids, and estrogen [32].
  • In a multiple regression analysis with age and body mass index (percent body fat) as fixed variables, it turned out that testosterone had a potent negative effect on serum leptin in boys, but not in girls [33].
  • Compared with Oriental women, Finnish women had 46% higher plasma estradiol (P < .01) and 124% higher plasma estrone sulfate (P < .01); however, after adjustment for differences in age and body mass index, only the difference in estrone sulfate remained statistically significant (P < .05) [34].

Gene context of Body Mass Index

  • After controlling for IGFBP-3, age, smoking, body mass index (weight in kg/[height in m]2), and alcohol intake, men in the highest quintile for IGF-I had an increased risk of colorectal cancer compared with men in the lowest quintile (relative risk [RR]=2.51; 95% confidence interval [CI]=1.15-5.46; P for trend = .02) [35].
  • We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients [36].
  • Hepatic CYP2E1 activity was assessed using the oral clearance (CL(PO)) of chlorzoxazone (CHZ) in 20 NDN and 17 age, gender, and body mass index (BMI)-matched controls [37].
  • There was no evidence of interaction between XRCC1 genotype and body mass index [38].
  • Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index [39].

Analytical, diagnostic and therapeutic context of Body Mass Index


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  14. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Maffei, M., Halaas, J., Ravussin, E., Pratley, R.E., Lee, G.H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S. Nat. Med. (1995) [Pubmed]
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  16. Inverse association of dietary fat with development of ischemic stroke in men. Gillman, M.W., Cupples, L.A., Millen, B.E., Ellison, R.C., Wolf, P.A. JAMA (1997) [Pubmed]
  17. Protective effect of fruits and vegetables on development of stroke in men. Gillman, M.W., Cupples, L.A., Gagnon, D., Posner, B.M., Ellison, R.C., Castelli, W.P., Wolf, P.A. JAMA (1995) [Pubmed]
  18. Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study. Michaud, D.S., Liu, S., Giovannucci, E., Willett, W.C., Colditz, G.A., Fuchs, C.S. J. Natl. Cancer Inst. (2002) [Pubmed]
  19. Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men. Giovannucci, E., Rimm, E.B., Ascherio, A., Stampfer, M.J., Colditz, G.A., Willett, W.C. J. Natl. Cancer Inst. (1995) [Pubmed]
  20. Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa. Martínez, M.E., Heddens, D., Earnest, D.L., Bogert, C.L., Roe, D., Einspahr, J., Marshall, J.R., Alberts, D.S. J. Natl. Cancer Inst. (1999) [Pubmed]
  21. Lipoprotein(a) levels and risk of coronary heart disease in men. The lipid Research Clinics Coronary Primary Prevention Trial. Schaefer, E.J., Lamon-Fava, S., Jenner, J.L., McNamara, J.R., Ordovas, J.M., Davis, C.E., Abolafia, J.M., Lippel, K., Levy, R.I. JAMA (1994) [Pubmed]
  22. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. Considine, R.V., Considine, E.L., Williams, C.J., Nyce, M.R., Magosin, S.A., Bauer, T.L., Rosato, E.L., Colberg, J., Caro, J.F. J. Clin. Invest. (1995) [Pubmed]
  23. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Ruhl, C.E., Everhart, J.E. Gastroenterology (2003) [Pubmed]
  24. Menopausal estrogen therapy and hip fractures. Paganini-Hill, A., Ross, R.K., Gerkins, V.R., Henderson, B.E., Arthur, M., Mack, T.M. Ann. Intern. Med. (1981) [Pubmed]
  25. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Nakai, K., Itoh, C., Miura, Y., Hotta, K., Musha, T., Itoh, T., Miyakawa, T., Iwasaki, R., Hiramori, K. Circulation (1994) [Pubmed]
  26. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Kern, P.A., Saghizadeh, M., Ong, J.M., Bosch, R.J., Deem, R., Simsolo, R.B. J. Clin. Invest. (1995) [Pubmed]
  27. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. Ahmad, F., Azevedo, J.L., Cortright, R., Dohm, G.L., Goldstein, B.J. J. Clin. Invest. (1997) [Pubmed]
  28. Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. Laine, H., Yki-Jarvinen, H., Kirvela, O., Tolvanen, T., Raitakari, M., Solin, O., Haaparanta, M., Knuuti, J., Nuutila, P. J. Clin. Invest. (1998) [Pubmed]
  29. Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease. The Heart and Estrogen/progestin Replacement Study. Simon, J.A., Hunninghake, D.B., Agarwal, S.K., Lin, F., Cauley, J.A., Ireland, C.C., Pickar, J.H. Ann. Intern. Med. (2001) [Pubmed]
  30. Treatment-induced blood pressure reduction and the risk of myocardial infarction. Alderman, M.H., Ooi, W.L., Madhavan, S., Cohen, H. JAMA (1989) [Pubmed]
  31. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. Gardner, C.D., Fortmann, S.P., Krauss, R.M. JAMA (1996) [Pubmed]
  32. Thyroid hormone use and bone mineral density in elderly women. Effects of estrogen. Schneider, D.L., Barrett-Connor, E.L., Morton, D.J. JAMA (1994) [Pubmed]
  33. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. Wabitsch, M., Blum, W.F., Muche, R., Braun, M., Hube, F., Rascher, W., Heinze, E., Teller, W., Hauner, H. J. Clin. Invest. (1997) [Pubmed]
  34. Estrogen metabolism and excretion in Oriental and Caucasian women. Adlercreutz, H., Gorbach, S.L., Goldin, B.R., Woods, M.N., Dwyer, J.T., Hämäläinen, E. J. Natl. Cancer Inst. (1994) [Pubmed]
  35. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. Ma, J., Pollak, M.N., Giovannucci, E., Chan, J.M., Tao, Y., Hennekens, C.H., Stampfer, M.J. J. Natl. Cancer Inst. (1999) [Pubmed]
  36. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Ribasés, M., Gratacòs, M., Fernández-Aranda, F., Bellodi, L., Boni, C., Anderluh, M., Cavallini, M.C., Cellini, E., Di Bella, D., Erzegovesi, S., Foulon, C., Gabrovsek, M., Gorwood, P., Hebebrand, J., Hinney, A., Holliday, J., Hu, X., Karwautz, A., Kipman, A., Komel, R., Nacmias, B., Remschmidt, H., Ricca, V., Sorbi, S., Wagner, G., Treasure, J., Collier, D.A., Estivill, X. Hum. Mol. Genet. (2004) [Pubmed]
  37. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Chalasani, N., Gorski, J.C., Asghar, M.S., Asghar, A., Foresman, B., Hall, S.D., Crabb, D.W. Hepatology (2003) [Pubmed]
  38. A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Duell, E.J., Holly, E.A., Bracci, P.M., Wiencke, J.K., Kelsey, K.T. Cancer Res. (2002) [Pubmed]
  39. Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index. Yang, Y., Chung, E.K., Zhou, B., Blanchong, C.A., Yu, C.Y., Füst, G., Kovács, M., Vatay, A., Szalai, C., Karádi, I., Varga, L. J. Immunol. (2003) [Pubmed]
  40. The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans. Prigeon, R.L., Røder, M.E., Porte, D., Kahn, S.E. J. Clin. Invest. (1996) [Pubmed]
  41. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Schmidt, M.I., Duncan, B.B., Sharrett, A.R., Lindberg, G., Savage, P.J., Offenbacher, S., Azambuja, M.I., Tracy, R.P., Heiss, G. Lancet (1999) [Pubmed]
  42. Insulin resistance-associated hepatic iron overload. Mendler, M.H., Turlin, B., Moirand, R., Jouanolle, A.M., Sapey, T., Guyader, D., Le Gall, J.Y., Brissot, P., David, V., Deugnier, Y. Gastroenterology (1999) [Pubmed]
  43. Long-term follow-up of cardiovascular risk factors in patients given chemotherapy for disseminated nonseminomatous testicular cancer. Gietema, J.A., Sleijfer, D.T., Willemse, P.H., Schraffordt Koops, H., van Ittersum, E., Verschuren, W.M., Kromhout, D., Sluiter, W.J., Mulder, N.H., de Vries, E.G. Ann. Intern. Med. (1992) [Pubmed]
  44. A prospective investigation of elevated lipoprotein (a) detected by electrophoresis and cardiovascular disease in women. The Framingham Heart Study. Bostom, A.G., Gagnon, D.R., Cupples, L.A., Wilson, P.W., Jenner, J.L., Ordovas, J.M., Schaefer, E.J., Castelli, W.P. Circulation (1994) [Pubmed]
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