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Khan, I.A. et al.

Khan, Mirza, Kumar, Verma, Qazi,

Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.

Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.[1]

References

Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus. Khan, I.A., Mirza, Z.M., Kumar, A., Verma, V., Qazi, G.N. Antimicrob. Agents Chemother. (2006) [Pubmed]

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