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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Potent algicides based on the cyanobacterial alkaloid nostocarboline.

[structure: see text] Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >or=100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >or=0.7 microM). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide.[1]


  1. Potent algicides based on the cyanobacterial alkaloid nostocarboline. Blom, J.F., Brütsch, T., Barbaras, D., Bethuel, Y., Locher, H.H., Hubschwerlen, C., Gademann, K. Org. Lett. (2006) [Pubmed]
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