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Raman, M. et al.

TGF-beta regulation by Emilin1: new links in the etiology of hypertension.

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.[1]

References

TGF-beta regulation by Emilin1: new links in the etiology of hypertension. Raman, M., Cobb, M.H. Cell (2006) [Pubmed]

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