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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CD8(+) recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.

Prevailing knowledge dictates that naive alphabeta T cells require activation in lymphoid tissues before differentiating into effector or memory T cells capable of trafficking to nonlymphoid tissues. Here we demonstrate that CD8(+) recent thymic emigrants (RTEs) migrated directly into the small intestine. CCR9, CCL25 and alpha(4)beta(7) integrin were required for gut entry of CD8(+) RTEs. After T cell receptor stimulation, intestinal CD8(+) RTEs proliferated and acquired a surface phenotype resembling that of intraepithelial lymphocytes. CD8(+) RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid organs. These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces.[1]

References

  1. CD8(+) recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Staton, T.L., Habtezion, A., Winslow, M.M., Sato, T., Love, P.E., Butcher, E.C. Nat. Immunol. (2006) [Pubmed]
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