- Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. Nakano, D., Kwak, C.J., Fujii, K., Ikemura, K., Satake, A., Ohkita, M., Takaoka, M., Ono, Y., Nakai, M., Tomimori, N., Kiso, Y., Matsumura, Y. J. Pharmacol. Exp. Ther. (2006)