Gene Review:
Nos3 - nitric oxide synthase 3, endothelial cell
Rattus norvegicus
Synonyms:
Constitutive NOS, EC-NOS, Endothelial NOS, NOS type III, NOSIII, ...
Ortiz,
Hong,
Garvin,
Tazi,
Moreau,
Hervé,
Dauvergne,
Cazals-Hatem,
Bert,
Poirel,
Rabiller,
Lebrec,
Murata,
Sato,
Hori,
Ozaki,
Karaki,
Liu,
Smith,
Appleton,
Darlington,
Bilkey,
Blumberg,
Wolf,
Arzt,
Lorenz,
Riegger,
Pfeifer,
Reiner,
Bloch,
Addicks,
Bayraktutan,
Sun,
Mayhan,
Heeringa,
van Goor,
Moshage,
Klok,
Huitema,
de Jager,
Schep,
Kallenberg,
Jang,
Lee,
Choi,
Park,
Lee,
Park,
Park,
Morimoto,
Kurahashi,
Shintani-Ishida,
Kawamura,
Miyashita,
Uji,
Tan,
Yoshida,
- Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. Liu, S., Premont, R.T., Kontos, C.D., Huang, J., Rockey, D.C. J. Biol. Chem. (2003)
- Dual role for nitric oxide in dynorphin spinal neurotoxicity. Hu, W.H., Li, F., Qiang, W.A., Liu, N., Wang, G.Q., Xiao, J., Liu, J.S., Liao, W.H., Jen, M.F. J. Neurotrauma (1999)
- Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs. Blumberg, F.C., Wolf, K., Arzt, M., Lorenz, C., Riegger, G.A., Pfeifer, M. J. Appl. Physiol. (2003)
- Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Jang, A.S., Lee, J.U., Choi, I.S., Park, K.O., Lee, J.H., Park, S.W., Park, C.S. Intensive care medicine. (2004)
- Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Musicki, B., Kramer, M.F., Becker, R.E., Burnett, A.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption. Sun, H., Mayhan, W.G. Alcohol. Clin. Exp. Res. (2005)
- Estrogen replacement suppresses stress-induced cardiovascular responses in ovariectomized rats. Morimoto, K., Kurahashi, Y., Shintani-Ishida, K., Kawamura, N., Miyashita, M., Uji, M., Tan, N., Yoshida, K. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Fulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Franke, T.F., Papapetropoulos, A., Sessa, W.C. Nature (1999)
- Enhanced peroxynitrite formation is associated with vascular aging. van der Loo, B., Labugger, R., Skepper, J.N., Bachschmid, M., Kilo, J., Powell, J.M., Palacios-Callender, M., Erusalimsky, J.D., Quaschning, T., Malinski, T., Gygi, D., Ullrich, V., Lüscher, T.F. J. Exp. Med. (2000)
- Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. Wiest, R., Das, S., Cadelina, G., Garcia-Tsao, G., Milstien, S., Groszmann, R.J. J. Clin. Invest. (1999)
- Beneficial effects of tetramethylpyrazine, an active constituent of Chinese herbs, on rats with endotoxemia. Liao, M.H., Wu, C.C., Yen, M.H. Proc. Natl. Sci. Counc. Repub. China B (1998)
- Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. Murata, T., Sato, K., Hori, M., Ozaki, H., Karaki, H. J. Biol. Chem. (2002)
- Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis. Heeringa, P., van Goor, H., Moshage, H., Klok, P.A., Huitema, M.G., de Jager, A., Schep, A.J., Kallenberg, C.G. Kidney Int. (1998)
- Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Bayraktutan, U. J. Mol. Cell. Cardiol. (2004)
- Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: role of Akt signaling. Tazi, K.A., Moreau, R., Hervé, P., Dauvergne, A., Cazals-Hatem, D., Bert, F., Poirel, O., Rabiller, A., Lebrec, D. Gastroenterology (2005)
- Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. Chen, S., Cao, L., Intengan, H.D., Humphreys, M., Gardner, D.G. J. Biol. Chem. (2002)
- Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. Gobeil, F., Zhu, T., Brault, S., Geha, A., Vazquez-Tello, A., Fortier, A., Barbaz, D., Checchin, D., Hou, X., Nader, M., Bkaily, G., Gratton, J.P., Heveker, N., Ribeiro-da-Silva, A., Peri, K., Bard, H., Chorvatova, A., D'Orléans-Juste, P., Goetzl, E.J., Chemtob, S. J. Biol. Chem. (2006)
- Localization of nitric oxide synthases during fracture healing. Zhu, W., Murrell, G.A., Lin, J., Gardiner, E.M., Diwan, A.D. J. Bone Miner. Res. (2002)
- Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats. Piech, A., Dessy, C., Havaux, X., Feron, O., Balligand, J.L. Cardiovasc. Res. (2003)
- Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Cernadas, M.R., Sánchez de Miguel, L., García-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, P., de Frutos, T., Rodríguez-Feo, J.A., Guerra, J., Caramelo, C., Casado, S., López-Farré, n.u.l.l. Circ. Res. (1998)
- The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Ling, Y., Zhang, J., Luo, B., Song, D., Liu, L., Tang, L., Stockard, C.R., Grizzle, W.E., Ku, D.D., Fallon, M.B. Hepatology (2004)
- Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. Iwase, K., Miyanaka, K., Shimizu, A., Nagasaki, A., Gotoh, T., Mori, M., Takiguchi, M. J. Biol. Chem. (2000)
- Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension. Lou , Y.K., Wen, C., Li, M., Adams, D.J., Wang , M.X., Yang, F., Morris, B.J., Whitworth, J.A. Hypertension (2001)
- Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. Schwartz, D., Mendonca, M., Schwartz, I., Xia, Y., Satriano, J., Wilson, C.B., Blantz, R.C. J. Clin. Invest. (1997)
- LPS inhibits endothelin-1-induced endothelial NOS activation in hepatic sinusoidal cells through a negative feedback involving caveolin-1. Kamoun, W.S., Karaa, A., Kresge, N., Merkel, S.M., Korneszczuk, K., Clemens, M.G. Hepatology (2006)
- An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M., Martasek, P., Roman, L.J., Masters, B.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., Gross, S.S. J. Biol. Chem. (1997)
- Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes. Lowe, E.R., Everett, A.C., Lee, A.J., Lau, M., Dunbar, A.Y., Berka, V., Tsai, A.L., Osawa, Y. Drug Metab. Dispos. (2005)
- Functional interaction of caveolin-1 and eNOS in myocardial capillary endothelium revealed by immunoelectron microscopy. Reiner, M., Bloch, W., Addicks, K. J. Histochem. Cytochem. (2001)
- Role of nitric oxide in traumatic brain injury in the rat. Wada, K., Chatzipanteli, K., Busto, R., Dietrich, W.D. J. Neurosurg. (1998)
- Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90. Ortiz, P.A., Hong, N.J., Garvin, J.L. Am. J. Physiol. Renal Physiol. (2004)
- Stimulatory effect of IGF-I and VEGF on eNOS message, protein expression, eNOS phosphorylation and nitric oxide production in rat glomeruli, and the involvement of PI3-K signaling pathway. Wang, Y., Nagase, S., Koyama, A. Nitric Oxide (2004)
- Mechanism of impaired nitric oxide synthase activity in skeletal muscle of streptozotocin-induced diabetic rats. Perreault, M., Dombrowski, L., Marette, A. Diabetologia (2000)
- Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Liu, P., Smith, P.F., Appleton, I., Darlington, C.L., Bilkey, D.K. Neuroscience (2003)
- TGF-beta(1) modulates NOS expression and phosphorylation of Akt/PKB in rat myocytes exposed to hypoxia-reoxygenation. Chen, H., Li, D., Saldeen, T., Mehta, J.L. Am. J. Physiol. Heart Circ. Physiol. (2001)
- Expression of nitric oxide synthase isoforms in bone and bone cell cultures. Helfrich, M.H., Evans, D.E., Grabowski, P.S., Pollock, J.S., Ohshima, H., Ralston, S.H. J. Bone Miner. Res. (1997)
- Increased nitric oxide synthase mRNA expression in the renal medulla of water-deprived rats. Shin, S.J., Lai, F.J., Wen, J.D., Lin, S.R., Hsieh, M.C., Hsiao, P.J., Tsai, J.H. Kidney Int. (1999)
- Uropathogenic Escherichia coli Alters Muscle Contractions in Rat Urinary Bladder via a Nitric Oxide Synthase-Related Signaling Pathway. Weng, T.I., Chen, W.J., Wu, H.Y., Liu, S.H. J. Infect. Dis. (2006)