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Lessons learned from Myc/Max/Mad knockout mice.

The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely those in which the N-myc, c-myc, L-myc, mad1, mxi1, mad3, mnt, or max genes have been targeted. A compilation of lessons we have learned from these myc/max/mad knockout mouse models, and suggestions as to where future efforts could be focused, are also presented.[1]

References

  1. Lessons learned from Myc/Max/Mad knockout mice. Pirity, M., Blanck, J.K., Schreiber-Agus, N. Curr. Top. Microbiol. Immunol. (2006) [Pubmed]
 
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