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Gene Review

Mxi1  -  Max interacting protein 1

Mus musculus

Synonyms: ENSMUSG00000067085, Gm10197, Mad2, Max interactor 1, Max-interacting protein 1, ...
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Disease relevance of Mxi1


High impact information on Mxi1

  • Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond reciprocal regulation of common gene targets [4].
  • Analysis of mouse mxi1 has led to the identification of two mxi1 transcript forms possessing open reading frames that differ in their capacity to encode a short amino-terminal alpha-helical domain [5].
  • Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner [6].
  • This cancer-prone phenotype may correlate with the enhanced ability of several mxi1-deficient cell types, including prostatic epithelium, to proliferate [6].
  • Consistent with these roles, mxi1 may be the tumour-suppressor gene that resides at region 24-26 of the long arm of chromosome 10 [6].

Biological context of Mxi1


Anatomical context of Mxi1


Other interactions of Mxi1

  • Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF [7].
  • Compensatory increases in Mxi1 and Mad3 transcripts, similar to those previously described in Mad1 null hematopoietic cells, were also seen [13].
  • Here, we sought to characterize more fully the physical properties of the second homologue, mSin3A and to determine whether the recruitment of mSin3A by Mxi1 is indeed required for anti-Myc activity [14].
  • Mnt: a novel Max-interacting protein and Myc antagonist [15].

Analytical, diagnostic and therapeutic context of Mxi1


  1. Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas. Engstrom, L.D., Youkilis, A.S., Gorelick, J.L., Zheng, D., Ackley, V., Petroff, C.A., Benson, L.Q., Coon, M.R., Zhu, X., Hanash, S.M., Wechsler, D.S. Neoplasia (2004) [Pubmed]
  2. Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. Taj, M.M., Tawil, R.J., Engstrom, L.D., Zeng, Z., Hwang, C., Sanda, M.G., Wechsler, D.S. Prostate (2001) [Pubmed]
  3. Novel expression patterns of the myc/max/mad transcription factor network in developing murine prostate gland. Luo, Q., Harmon, E., Timms, B.G., Kretzner, L. J. Urol. (2001) [Pubmed]
  4. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. O'Hagan, R.C., Schreiber-Agus, N., Chen, K., David, G., Engelman, J.A., Schwab, R., Alland, L., Thomson, C., Ronning, D.R., Sacchettini, J.C., Meltzer, P., DePinho, R.A. Nat. Genet. (2000) [Pubmed]
  5. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I., DePinho, R.A. Cell (1995) [Pubmed]
  6. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Schreiber-Agus, N., Meng, Y., Hoang, T., Hou, H., Chen, K., Greenberg, R., Cordon-Cardo, C., Lee, H.W., DePinho, R.A. Nature (1998) [Pubmed]
  7. Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF. Lee, T.C., Ziff, E.B. J. Biol. Chem. (1999) [Pubmed]
  8. Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Edelhoff, S., Ayer, D.E., Zervos, A.S., Steingrímsson, E., Jenkins, N.A., Copeland, N.G., Eisenman, R.N., Brent, R., Disteche, C.M. Oncogene (1994) [Pubmed]
  9. Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Gupta, K., Anand, G., Yin, X., Grove, L., Prochownik, E.V. Oncogene (1998) [Pubmed]
  10. Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells. Dezfouli, S., Bakke, A., Huang, J., Wynshaw-Boris, A., Hurlin, P.J. Mol. Cell. Biol. (2006) [Pubmed]
  11. Expression, regulation and polymorphism of the mxi1 genes. Shimizu, E., Shirasawa, H., Kodama, K., Sato, T., Simizu, B. Gene (1996) [Pubmed]
  12. Follicle-stimulating hormone induced changes in gene expression of murine testis. Sadate-Ngatchou, P.I., Pouchnik, D.J., Griswold, M.D. Mol. Endocrinol. (2004) [Pubmed]
  13. Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones. Yin, X.Y., Grove, L.E., Prochownik, E.V. Oncogene (2001) [Pubmed]
  14. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. Rao, G., Alland, L., Guida, P., Schreiber-Agus, N., Chen, K., Chin, L., Rochelle, J.M., Seldin, M.F., Skoultchi, A.I., DePinho, R.A. Oncogene (1996) [Pubmed]
  15. Mnt: a novel Max-interacting protein and Myc antagonist. Hurlin, P.J., Qúeva, C., Eisenman, R.N. Curr. Top. Microbiol. Immunol. (1997) [Pubmed]
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