- ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., Buttle, D.J., Woodroofe, M.N. Brain Res. (2006)