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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Analysis of consumer cosmetic products for phthalate esters.

A rapid and sensitive reverse-phase HPLC method with UV detection was developed for the quantitation of dimethyl phthalate (DMP), diethyl phthalate (DEP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP) in cosmetic preparations. Average recoveries of the phthalate esters were better than 90%. In a survey of 48 consumer cosmetic products, including hair care products, deodorants, lotions and creams, nail products, fragrances, and body washes, most products were found to contain at least one phthalate ester. DEP was detected most frequently at concentrations up to 38,663 ppm. DBP was found in fewer products, but at levels up to 59,815 ppm. Based on the available exposure and toxicity data, the FDA has concluded that there is insufficient data to conclude that a human health hazard exists from exposure to phthalate esters from cosmetic products.[1]


  1. Analysis of consumer cosmetic products for phthalate esters. Hubinger, J.C., Havery, D.C. Journal of cosmetic science. (2006) [Pubmed]
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