Disease relevance of Avolin

• Metabolism of dimethylphthalate by Micrococcus sp. strain 12B [1].
• TWO BACTERIAL STRAINS: Arthrobacter sp. and Sphingomonas paucimobilis were isolated from soil by enrichment cultures using dimethylphthalate (DMP) or monomethylphthalate (MMP) as sole carbon source, respectively [2].
• Both DMP and DBP were found to produce significant increases in the mutant frequency in the mouse lymphoma assay in the presence but not in the absence of an Aroclor-induced rat liver activation system (S-9) [3].

High impact information on Avolin

• No significant changes in gene expression were detected in the nondevelopmentally toxic phthalate group (DMP, DEP, and DOTP) [4].
• The absorption of undiluted phthalate diesters [dimethyl phthalate (DMP), diethylphthalate (DEP), dibutyl phthalate (DBP) and di-(2-ethylhexyl)phthalate (DEHP)] has been measured in vitro through human and rat epidermal membranes [5].
• Activity of aminopyrine N-demethylase and aniline hydroxylase was also inhibited by dimethyl phthalate (DMP) and dibutyl phthalate (DBP) after a single oral administration [6].
• The dimethyl phthalate (DMP), diethyl phthalate (DEP) and dibutyl phthalate (DBP) were well separated within 16min by a C-18 column and eluted gradient from 40 to 90% aqueous acetonitrile (at pH 6.0) and 1.0 to 1.5mL/min flow-rate [7].
• Fiber introduction mass spectrometry (FIMS)-a direct coupling of SPME and MS-using selective ion monitoring (SIM) was used to detect and quantify dimethylphthalate (DMP), diethylphthalate (DEP) and dipropylphthalate (DPP) in mineral water [8].

Biological context of Avolin

• Dimethylphthalate hydrolysis by specific microbial esterase [2].

Associations of Avolin with other chemical compounds

• Thermodynamics of inclusion of alpha- and beta-cyclodextrins (CDs) with three diester precursors of polyesters, dimethyl terephthalate (DMT), dimethyl isophthalate (DMI), and dimethyl phthalate (DMP) were studied with different fluorescence spectroscopy techniques [9].
• Aldehyde metabolites of the de-esterified alcohols are postulated to play a role in the positive results for DMP and DBP [3].
• The LC50 values for DMP, DEP, DBP, and BBP were 28.1, 4.21, 0.63, and 0.46 mg/L for H. azteca; 68.2, 31.0, 2.64, and > 1.76 mg/L for C. tentans; and 246, 102, 2.48, and 1.23 mg/L for L. variegatus, respectively [10].
• Comparative activity of three repellents viz., diethyl-m-toluamide (DEET), diethyl phenyl-acetamide (DEPA) and dimethylphthalate (DMP) against bedbugs Cimex hemipterus (Fabr) was studied by applying repellent solution on the shaven skin of rabbits [11].
• DBP, DEP, DMP and an unknown diester were produced from DEHP [12].

Gene context of Avolin

• DEP and DBP were also in abundance, and DMP was rarely detected [13].

Analytical, diagnostic and therapeutic context of Avolin

• A rapid and sensitive reverse-phase HPLC method with UV detection was developed for the quantitation of dimethyl phthalate (DMP), diethyl phthalate (DEP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP) in cosmetic preparations [14].

References