The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 

The ClC-3 Cl- channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells.

The volume-regulated Cl(-) current (I(Cl.vol)) is responsible for the transmembrane Cl(-) transport that is involved in cell volume regulatory mechanisms. Although the regulation of cell volume is a fundamental function of healthy cells for maintaining constant size, the molecular genetic identification of I(Cl.vol) is still being debated. Recent studies in vascular smooth muscle support the idea that ClC-3, a member of the voltage-gated ClC Cl(-) channel family, is the molecular component involved in the activation or regulation of I(Cl.vol). Moreover, gene-targeting studies in vascular smooth muscle cells (VSMCs) and other cell types indicate emerging roles of ClC-3 in cell proliferation and apoptosis. These findings indicate that ClC-3 might be involved in modulating vascular remodeling in hypertension and arteriosclerosis.[1]

References

  1. The ClC-3 Cl- channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells. Guan, Y.Y., Wang, G.L., Zhou, J.G. Trends Pharmacol. Sci. (2006) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities