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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus.

The present study investigated the changes in the expression of regulators of G-protein- coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.[1]

References

  1. Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus. Shelat, P.B., Coulibaly, A.P., Wang, Q., Sun, A.Y., Sun, G.Y., Simonyi, A. Neurosci. Lett. (2006) [Pubmed]
 
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