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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of acute xerostomia on vocal function.

OBJECTIVE: To evaluate whether xerostomia can affect vocal function in an experimental model. DESIGN: Randomized controlled study. SETTING: Academic center. SUBJECTS: Twenty healthy young men. INTERVENTIONS: Glycopyrrolate was administered to induce acute xerostomia in 10 men, and saline was administered to 10 men who served as controls. MAIN OUTCOME MEASURES: Whole salivary flow rate and dry mouth scale were time-serially measured, and subjective and objective vocal functions were checked before and after treatment. The salivary and vocal functions were compared between groups. RESULTS: Significant salivary hypofunction and symptoms developed within 90 minutes after the administration of glycopyrrolate. Vocal effort and phonation threshold pressure significantly increased (P<.005) and voice range profiles decreased in the xerostomia group (P = .003) but not in the control group. Other voice parameters were comparable between groups (P>.05). High correlations were also found between salivary and vocal parameters. CONCLUSION: Our findings suggest that vocal function can be affected by xerostomia.[1]


  1. The effect of acute xerostomia on vocal function. Roh, J.L., Kim, H.S., Kim, A.Y. Arch. Otolaryngol. Head Neck Surg. (2006) [Pubmed]
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