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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Models, Theoretical

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Disease relevance of Models, Theoretical


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High impact information on Models, Theoretical

  • In this paper, we review the high-resolution structure data from the bacterial porins, as well as recent theoretical studies, in the context of biophysical and biochemical observations and discuss the molecular mechanisms responsible for the transport of solutes through porin channels [11].
  • The immature female hypophysectomized rate sequentially primed with estradiol, FSH and LH was used as the experimental model [12].
  • Here, we report three-dimensional images of the complete electron emission pattern for the single ionization of helium by the impact of C6+ ions of energy 100 MeV per a.m.u. (a four-body system) and observe features that have not been predicted by any published theoretical model [13].
  • IL-13 is thus both necessary and sufficient for experimental models of asthma [14].
  • We show experimentally that Dpp is widely diffusible in the presence of Sog but tightly localized in its absence, thus validating a central prediction of our theoretical study [15].

Chemical compound and disease context of Models, Theoretical


Biological context of Models, Theoretical


Anatomical context of Models, Theoretical

  • Such a direct approach would involve isolation or molecular identification of the potentially infecting organisms from the thyroid gland and the subsequent induction of AITD in an experimental model [26].
  • Consequently, during seizures, inhibition by GABA may be diminished by the zinc released from aberrantly sprouted mossy fiber terminals of granule cells, which are found in many experimental models of epilepsy and in human temporal lobe epilepsy [27].
  • Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3 [28].
  • However, as an experimental model for producing neuronal depletion in the neostriatum, excitotoxic injury has allowed the study of other neuronal characteristics of HD such as progressive atrophy and regeneration; it has also permitted extensive exploration of the anatomical and functional recovery induced by intrastriatal grafts [29].
  • The results suggest that, in accordance with the earlier observation made in experimental models, T lymphocyte reactivity to human HSP60 in this subgroup of JCA patients may be part of T cell regulatory mechanisms that control the development of arthritis [30].

Associations of Models, Theoretical with chemical compounds

  • A mathematical model incorporating K+ channels, reversible uptake carriers and NMDA (N-methyl-D-aspartate) receptor channels reproduces the main features of the response to ischaemia [31].
  • But theoretical models suggest that the initial form of nitrogen in Titan's atmosphere may have been NH3 [32].
  • Minocycline mediates neuroprotection in experimental models of neurodegeneration [33].
  • Theoretical models of mantle flow have been used to infer that, for progressive simple shear imparted by the motion of an overriding tectonic plate, the a-axes of olivine crystals should align themselves parallel to the direction of plate motion [34].
  • A unique experimental model is described, where natural immunologic tolerance to a well-defined soluble native antigen (murine C5) is examined in congenic strains of mice that differ only by the presence or the absence of C5 [35].

Gene context of Models, Theoretical


Analytical, diagnostic and therapeutic context of Models, Theoretical


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  2. Severely impaired adipsin expression in genetic and acquired obesity. Flier, J.S., Cook, K.S., Usher, P., Spiegelman, B.M. Science (1987) [Pubmed]
  3. Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944. Sakuragawa, N., Sakuragaw, M., Kuwabara, T., Pentchev, P.G., Barranger, J.A., Brady, R.O. Science (1977) [Pubmed]
  4. Embryonal neoplasms in the opossum: a new model for solid tumors of infancy and childhood. Jurgelski, W., Hudson, P.M., Falk, H.L., Kotin, P. Science (1976) [Pubmed]
  5. Pathogenetic difference between collagen arthritis and adjuvant arthritis. Kaibara, N., Hotokebuchi, T., Takagishi, K., Katsuki, I., Morinaga, M., Arita, C., Jingushi, S. J. Exp. Med. (1984) [Pubmed]
  6. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., Mucke, L. Nature (1997) [Pubmed]
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  8. Eicosanoids in experimental and human renal disease. Stork, J.E., Rahman, M.A., Dunn, M.J. Am. J. Med. (1986) [Pubmed]
  9. Learned helplessness: an experimental model of the DST in rats. Haracz, J.L., Minor, T.R., Wilkins, J.N., Zimmermann, E.G. Biol. Psychiatry (1988) [Pubmed]
  10. Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat. Soszynski, P.A., Frohman, L.A. Endocrinology (1992) [Pubmed]
  11. Structure and functional mechanism of porins. Jap, B.K., Walian, P.J. Physiol. Rev. (1996) [Pubmed]
  12. Hormonal regulation of ovarian cellular proliferation. Rao, M.C., Midgley, A.R., Richards, J.S. Cell (1978) [Pubmed]
  13. Three-dimensional imaging of atomic four-body processes. Schulz, M., Moshammer, R., Fischer, D., Kollmus, H., Madison, D.H., Jones, S., Ullrich, J. Nature (2003) [Pubmed]
  14. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, D.A., Huang, X., Koth, L.L., Chang, G.H., Dolganov, G.M., Zhu, Z., Elias, J.A., Sheppard, D., Erle, D.J. Nat. Med. (2002) [Pubmed]
  15. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Eldar, A., Dorfman, R., Weiss, D., Ashe, H., Shilo, B.Z., Barkai, N. Nature (2002) [Pubmed]
  16. Adipsin and complement factor D activity: an immune-related defect in obesity. Rosen, B.S., Cook, K.S., Yaglom, J., Groves, D.L., Volanakis, J.E., Damm, D., White, T., Spiegelman, B.M. Science (1989) [Pubmed]
  17. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. Bruner, K.L., Matrisian, L.M., Rodgers, W.H., Gorstein, F., Osteen, K.G. J. Clin. Invest. (1997) [Pubmed]
  18. Efficacy of antilipopolysaccharide and anti-tumor necrosis factor monoclonal antibodies in a neutropenic rat model of Pseudomonas sepsis. Opal, S.M., Cross, A.S., Sadoff, J.C., Collins, H.H., Kelly, N.M., Victor, G.H., Palardy, J.E., Bodmer, M.W. J. Clin. Invest. (1991) [Pubmed]
  19. Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases. Taraboletti, G., Garofalo, A., Belotti, D., Drudis, T., Borsotti, P., Scanziani, E., Brown, P.D., Giavazzi, R. J. Natl. Cancer Inst. (1995) [Pubmed]
  20. Some biological characteristics of transplantable lines of mouse adenocarcinomas of the colon. Cowen, D.M., Double, J.A., Cowen, P.N. J. Natl. Cancer Inst. (1980) [Pubmed]
  21. A model for the adjustment of the mitotic clock by cyclin and MPF levels. Norel, R., Agur, Z. Science (1991) [Pubmed]
  22. Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. Romano, M., Ricci, V., Di Popolo, A., Sommi, P., Del Vecchio Blanco, C., Bruni, C.B., Ventura, U., Cover, T.L., Blaser, M.J., Coffey, R.J., Zarrilli, R. J. Clin. Invest. (1998) [Pubmed]
  23. Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes. Turner, R.C., Mathews, D.R., Holman, R.R., Peto, J. Lancet (1982) [Pubmed]
  24. Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. Aubert, A., Costalat, R., Magistretti, P.J., Pellerin, L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Bengzon, J., Kokaia, Z., Elmér, E., Nanobashvili, A., Kokaia, M., Lindvall, O. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  26. Infection, thyroid disease, and autoimmunity. Tomer, Y., Davies, T.F. Endocr. Rev. (1993) [Pubmed]
  27. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Buhl, E.H., Otis, T.S., Mody, I. Science (1996) [Pubmed]
  28. Cellular mechanism of neuronal synchronization in epilepsy. Traub, R.D., Wong, R.K. Science (1982) [Pubmed]
  29. Excitotoxic injury of the neostriatum: a model for Huntington's disease. DiFiglia, M. Trends Neurosci. (1990) [Pubmed]
  30. Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. de Graeff-Meeder, E.R., van Eden, W., Rijkers, G.T., Prakken, B.J., Kuis, W., Voorhorst-Ogink, M.M., van der Zee, R., Schuurman, H.J., Helders, P.J., Zegers, B.J. J. Clin. Invest. (1995) [Pubmed]
  31. Glutamate release in severe brain ischaemia is mainly by reversed uptake. Rossi, D.J., Oshima, T., Attwell, D. Nature (2000) [Pubmed]
  32. High-temperature shock formation of N2 and organics on primordial Titan. McKay, C.P., Scattergood, T.W., Pollack, J.B., Borucki, W.J., Van Ghyseghem, H.T. Nature (1988) [Pubmed]
  33. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Zhu, S., Stavrovskaya, I.G., Drozda, M., Kim, B.Y., Ona, V., Li, M., Sarang, S., Liu, A.S., Hartley, D.M., Wu, d.u. .C., Gullans, S., Ferrante, R.J., Przedborski, S., Kristal, B.S., Friedlander, R.M. Nature (2002) [Pubmed]
  34. Resistance to mantle flow inferred from the electromagnetic strike of the Australian upper mantle. Simpson, F. Nature (2001) [Pubmed]
  35. A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness. Harris, D.E., Cairns, L., Rosen, F.S., Borel, Y. J. Exp. Med. (1982) [Pubmed]
  36. Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. DeForge, L.E., Fantone, J.C., Kenney, J.S., Remick, D.G. J. Clin. Invest. (1992) [Pubmed]
  37. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Lev Bar-Or, R., Maya, R., Segel, L.A., Alon, U., Levine, A.J., Oren, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  38. Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis. Giuliani, N., Colla, S., Lazzaretti, M., Sala, R., Roti, G., Mancini, C., Bonomini, S., Lunghi, P., Hojden, M., Genestreti, G., Svaldi, M., Coser, P., Fattori, P.P., Sammarelli, G., Gazzola, G.C., Bataille, R., Almici, C., Caramatti, C., Mangoni, L., Rizzoli, V. Blood (2003) [Pubmed]
  39. Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Krenger, W., Falzarano, G., Delmonte, J., Snyder, K.M., Byon, J.C., Ferrara, J.L. Blood (1996) [Pubmed]
  40. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Piovan, E., Tosello, V., Indraccolo, S., Cabrelle, A., Baesso, I., Trentin, L., Zamarchi, R., Tamamura, H., Fujii, N., Semenzato, G., Chieco-Bianchi, L., Amadori, A. Blood (2005) [Pubmed]
  41. Portacaval shunt as an experimental model of impaired hepatic release of vitamin A in liver disease. Schölmerich, J., Fabian, M., Tauber, R., Löhle, E., Köttgen, E., Grün, M., Wietholtz, H., Baumgartner, U., Gerok, W. Gastroenterology (1991) [Pubmed]
  42. Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model. Herrero, P., Markham, J., Shelton, M.E., Weinheimer, C.J., Bergmann, S.R. Circulation (1990) [Pubmed]
  43. Antimineralization effect of ethanol and experimental model of accelerated calcification study in heart valve bioprostheses. Chanda, J., Kuribayashi, R., Abe, T. Circulation (1997) [Pubmed]
  44. Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling. Swameye, I., Muller, T.G., Timmer, J., Sandra, O., Klingmuller, U. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  45. In vitro human immunodeficiency virus-1 infection of purified hematopoietic progenitors in single-cell culture. Chelucci, C., Hassan, H.J., Locardi, C., Bulgarini, D., Pelosi, E., Mariani, G., Testa, U., Federico, M., Valtieri, M., Peschle, C. Blood (1995) [Pubmed]
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