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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Models, Theoretical

 
 
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Disease relevance of Models, Theoretical

 

Psychiatry related information on Models, Theoretical

 

High impact information on Models, Theoretical

  • In this paper, we review the high-resolution structure data from the bacterial porins, as well as recent theoretical studies, in the context of biophysical and biochemical observations and discuss the molecular mechanisms responsible for the transport of solutes through porin channels [11].
  • The immature female hypophysectomized rate sequentially primed with estradiol, FSH and LH was used as the experimental model [12].
  • Here, we report three-dimensional images of the complete electron emission pattern for the single ionization of helium by the impact of C6+ ions of energy 100 MeV per a.m.u. (a four-body system) and observe features that have not been predicted by any published theoretical model [13].
  • IL-13 is thus both necessary and sufficient for experimental models of asthma [14].
  • We show experimentally that Dpp is widely diffusible in the presence of Sog but tightly localized in its absence, thus validating a central prediction of our theoretical study [15].
 

Chemical compound and disease context of Models, Theoretical

 

Biological context of Models, Theoretical

 

Anatomical context of Models, Theoretical

  • Such a direct approach would involve isolation or molecular identification of the potentially infecting organisms from the thyroid gland and the subsequent induction of AITD in an experimental model [26].
  • Consequently, during seizures, inhibition by GABA may be diminished by the zinc released from aberrantly sprouted mossy fiber terminals of granule cells, which are found in many experimental models of epilepsy and in human temporal lobe epilepsy [27].
  • Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3 [28].
  • However, as an experimental model for producing neuronal depletion in the neostriatum, excitotoxic injury has allowed the study of other neuronal characteristics of HD such as progressive atrophy and regeneration; it has also permitted extensive exploration of the anatomical and functional recovery induced by intrastriatal grafts [29].
  • The results suggest that, in accordance with the earlier observation made in experimental models, T lymphocyte reactivity to human HSP60 in this subgroup of JCA patients may be part of T cell regulatory mechanisms that control the development of arthritis [30].
 

Associations of Models, Theoretical with chemical compounds

  • A mathematical model incorporating K+ channels, reversible uptake carriers and NMDA (N-methyl-D-aspartate) receptor channels reproduces the main features of the response to ischaemia [31].
  • But theoretical models suggest that the initial form of nitrogen in Titan's atmosphere may have been NH3 [32].
  • Minocycline mediates neuroprotection in experimental models of neurodegeneration [33].
  • Theoretical models of mantle flow have been used to infer that, for progressive simple shear imparted by the motion of an overriding tectonic plate, the a-axes of olivine crystals should align themselves parallel to the direction of plate motion [34].
  • A unique experimental model is described, where natural immunologic tolerance to a well-defined soluble native antigen (murine C5) is examined in congenic strains of mice that differ only by the presence or the absence of C5 [35].
 

Gene context of Models, Theoretical

 

Analytical, diagnostic and therapeutic context of Models, Theoretical

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