The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices.

Rat hippocampal slices were used to examine the effects of 2-amino-3-phosphonopropionate (AP3), an inhibitor of phosphatidylinositol (PI) turnover linked to metabotropic quisqualate receptors, on the development and maintenance of long-term potentiation (LTP) in area CA1. When perfused for 5 min prior to tetanization at concentrations of 100-1000 microM, D,L-AP3 had no effect on baseline synaptic transmission but blocked posttetanic potentiation (PTP) and the induction of LTP. Unlike the N-methyl-D-aspartate (NMDA) antagonists, 2-amino-5-phosphonovalerate (AP5) and MK-801, AP3 eliminated the late phase of LTP when applied immediately after tetanization. These data support the hypothesis that PI turnover is a factor in the expression and maintenance of LTP.[1]

References

 
WikiGenes - Universities