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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The oncofetal gene Pem specifies a divergent paired class homeodomain.

The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer.[1]

References

  1. The oncofetal gene Pem specifies a divergent paired class homeodomain. Rayle, R.E. Dev. Biol. (1991) [Pubmed]
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