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Gene Review

Rhox5  -  reproductive homeobox 5

Mus musculus

Synonyms: AA409564, Homeobox protein Pem, Homeobox protein Rhox5, Pem, Placenta and embryonic expression protein, ...
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Disease relevance of Rhox5


High impact information on Rhox5


Biological context of Rhox5


Anatomical context of Rhox5


Associations of Rhox5 with chemical compounds

  • In the present study, we identified promoter sequences from the Pem homeobox gene that direct Sertoli cell-specific expression in an androgen-dependent and stage-specific manner [9].
  • Injection of either testosterone or luteinizing hormone (LH) into hypophysectomized and hpg/hpg mice restored Pem expression in the testes to normal levels [13].
  • The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer [14].
  • Pem mRNA is induced 35-fold in ES cells differentiated in the absence of retinoic acid [1].
  • The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase pull-down assay, and the possible interaction model was suggested [15].

Other interactions of Rhox5


Analytical, diagnostic and therapeutic context of Rhox5


  1. The oncofetal gene Pem encodes a homeodomain and is regulated in primordial and pre-muscle stem cells. Sasaki, A.W., Doskow, J., MacLeod, C.L., Rogers, M.B., Gudas, L.J., Wilkinson, M.F. Mech. Dev. (1991) [Pubmed]
  2. Transfection with steroid-responsive reporter constructs shows glucocorticoid rather than androgen responsiveness in cultured Sertoli cells. Denolet, E., Gendt, K.D., Swinnen, J.V., Verrijdt, G., Deboel, L., Roskams, T., Verhoeven, G. J. Steroid Biochem. Mol. Biol. (2006) [Pubmed]
  3. Rhox: a new homeobox gene cluster. Maclean, J.A., Chen, M.A., Wayne, C.M., Bruce, S.R., Rao, M., Meistrich, M.L., Macleod, C., Wilkinson, M.F. Cell (2005) [Pubmed]
  4. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. De Gendt, K., Swinnen, J.V., Saunders, P.T., Schoonjans, L., Dewerchin, M., Devos, A., Tan, K., Atanassova, N., Claessens, F., Lécureuil, C., Heyns, W., Carmeliet, P., Guillou, F., Sharpe, R.M., Verhoeven, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Normal gonadal development in mice lacking GPBOX, a homeobox protein expressed in germ cells at the onset of sexual dimorphism. Takasaki, N., Rankin, T., Dean, J. Mol. Cell. Biol. (2001) [Pubmed]
  6. Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Kobayashi, S., Isotani, A., Mise, N., Yamamoto, M., Fujihara, Y., Kaseda, K., Nakanishi, T., Ikawa, M., Hamada, H., Abe, K., Okabe, M. Curr. Biol. (2006) [Pubmed]
  7. Menin interacts directly with the homeobox-containing protein Pem. Lemmens, I.H., Forsberg, L., Pannett, A.A., Meyen, E., Piehl, F., Turner, J.J., Van de Ven, W.J., Thakker, R.V., Larsson, C., Kas, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. New androgen response elements in the murine pem promoter mediate selective transactivation. Barbulescu, K., Geserick, C., Schüttke, I., Schleuning, W.D., Haendler, B. Mol. Endocrinol. (2001) [Pubmed]
  9. Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo. Rao, M.K., Wayne, C.M., Meistrich, M.L., Wilkinson, M.F. Mol. Endocrinol. (2003) [Pubmed]
  10. The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Denolet, E., De Gendt, K., Allemeersch, J., Engelen, K., Marchal, K., Van Hummelen, P., Tan, K.A., Sharpe, R.M., Saunders, P.T., Swinnen, J.V., Verhoeven, G. Mol. Endocrinol. (2006) [Pubmed]
  11. The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development. Lin, T.P., Labosky, P.A., Grabel, L.B., Kozak, C.A., Pitman, J.L., Kleeman, J., MacLeod, C.L. Dev. Biol. (1994) [Pubmed]
  12. A novel oncofetal gene is expressed in a stage-specific manner in murine embryonic development. Wilkinson, M.F., Kleeman, J., Richards, J., MacLeod, C.L. Dev. Biol. (1990) [Pubmed]
  13. Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis. Lindsey, J.S., Wilkinson, M.F. Dev. Biol. (1996) [Pubmed]
  14. The oncofetal gene Pem specifies a divergent paired class homeodomain. Rayle, R.E. Dev. Biol. (1991) [Pubmed]
  15. Interaction of mouse Pem protein and cell division cycle 37 homolog. Guo, F., Li, Y.Q., Li, S.Q., Luo, Z.W., Zhang, X., Tang, D.S., Zhou, T.H. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]
  16. Forced expression of the homeobox-containing gene Pem blocks differentiation of embryonic stem cells. Fan, Y., Melhem, M.F., Chaillet, J.R. Dev. Biol. (1999) [Pubmed]
  17. The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2 are closely linked in the proximal region of the mouse X chromosome. Sutton, K.A., Wilkinson, M.F. Genomics (1997) [Pubmed]
  18. Rapid evolution of a homeodomain: evidence for positive selection. Sutton, K.A., Wilkinson, M.F. J. Mol. Evol. (1997) [Pubmed]
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