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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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3-Methyl-4-chlorophenol for prion decontamination of medical devices.

Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrP(Sc) sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.[1]

References

  1. 3-Methyl-4-chlorophenol for prion decontamination of medical devices. Riemer, C., Bamme, T., Fai Mok, S.W., Baier, M. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2006) [Pubmed]
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