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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo.

OBJECTIVES: Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model. METHODS: The trypanocidal activity of the compound was evaluated by clinical, parasitological, histopathological and biochemical investigations. RESULTS: Treatment with DB569 significantly reduced cardiac parasitism, partially increased the survival rates of mice and lowered the levels of alanine aminotransferase and creatinine indicating a protective role against renal and hepatic lesions caused by the parasite infection. CONCLUSIONS: Altogether, the data support the potential effect of this class of compounds against T. cruzi and motivate the screening of new diamidines for efficacy against Chagas' disease.[1]

References

  1. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. de Souza, E.M., Oliveira, G.M., Boykin, D.W., Kumar, A., Hu, Q., De Nazaré C Soeiro, M. J. Antimicrob. Chemother. (2006) [Pubmed]
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