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MeSH Review

Chagas Disease

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Disease relevance of Chagas Disease


Psychiatry related information on Chagas Disease

  • Antibodies (Abs) were purified from pooled sera of patients with either indeterminate (IND or I) or cardiac (CARD or C) Chagas' disease, on either epimastigote (EPI or E) or amastigote-enriched (AMAST or A) antigen (Ag) columns and their idiotypic (Id) expression examined [6].

High impact information on Chagas Disease

  • Of the 25 patients, 18 had been treated for coronary artery disease or idiopathic dilated cardiomyopathy for up to 108 months before the diagnosis of Chagas' disease was considered [7].
  • Transmission of Chagas' disease by transfusion of blood containing Trypanosoma cruzi has often been reported, and gentian violet, a triarylmethane dye, is widely used by blood banks in attempts to eliminate such transmission [8].
  • Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol [9].
  • Analysis of trypomastigote transfectants expressing various cysteine proteinase isoforms showed that invasion competence is linked to the kinin releasing activity of cruzipain, herein proposed as a factor of virulence in Chagas' disease [10].
  • The virulence-promoting activity of soluble trans-sialidase in the mouse model may be physiologically relevant because it was achieved with tiny doses, approximately 1-2 microgram/kg, raising the possibility that neutralization of the enzyme with specific probes could impair the development of Chagas' disease [11].

Chemical compound and disease context of Chagas Disease


Biological context of Chagas Disease


Anatomical context of Chagas Disease


Gene context of Chagas Disease


Analytical, diagnostic and therapeutic context of Chagas Disease


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  2. Functional implications of circulating muscarinic cholinergic receptor autoantibodies in chagasic patients with achalasia. Goin, J.C., Sterin-Borda, L., Bilder, C.R., Varrica, L.M., Iantorno, G., Ríos, M.C., Borda, E. Gastroenterology (1999) [Pubmed]
  3. Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design. Krauth-Siegel, R.L., Schöneck, R. FASEB J. (1995) [Pubmed]
  4. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. Colli, W. FASEB J. (1993) [Pubmed]
  5. Characterization of a membrane antigen of Leishmania amazonensis that stimulates human immune responses. Burns, J.M., Scott, J.M., Carvalho, E.M., Russo, D.M., March, C.J., Van Ness, K.P., Reed, S.G. J. Immunol. (1991) [Pubmed]
  6. Antibodies reactive to Trypanosoma cruzi epimastigotes or amastigotes express different idiotypic patterns if from patients with different clinical forms of Chagas' disease. Ribeiro-Rodrigues, R., Colley, D.G., Correa-Oliveira, R., Carter, C.E. Scand. J. Immunol. (1996) [Pubmed]
  7. Chagas' heart disease in the United States. Hagar, J.M., Rahimtoola, S.H. N. Engl. J. Med. (1991) [Pubmed]
  8. Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Docampo, R., Moreno, S.N., Muniz, R.P., Cruz, F.S., Mason, R.P. Science (1983) [Pubmed]
  9. Vertebrate cells express protozoan antigen after hybridization. Crane, M.S., Dvorak, J.A. Science (1980) [Pubmed]
  10. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors. Scharfstein, J., Schmitz, V., Morandi, V., Capella, M.M., Lima, A.P., Morrot, A., Juliano, L., Müller-Esterl, W. J. Exp. Med. (2000) [Pubmed]
  11. Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease. Chuenkova, M., Pereira, M.E. J. Exp. Med. (1995) [Pubmed]
  12. Should benznidazole be used in chronic Chagas' disease? Bestetti, R.B. Lancet (1997) [Pubmed]
  13. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. de Andrade, A.L., Zicker, F., de Oliveira, R.M., Almeida Silva, S., Luquetti, A., Travassos, L.R., Almeida, I.C., de Andrade, S.S., de Andrade, J.G., Martelli, C.M. Lancet (1996) [Pubmed]
  14. Dinitrochlorobenzene and Chagas' disease. Stricker, R.B., Goldberg, B. Lancet (1995) [Pubmed]
  15. Neural and hormonal peptides in rectal biopsy specimens from patients with Chagas' disease and chronic autonomic failure. Long, R.G., Bishop, A.E., Barnes, A.J., Albuquerque, R.H., O'Shaughnessy, D.J., McGregor, G.P., Bannister, R., Polak, J.M., Bloom, S.R. Lancet (1980) [Pubmed]
  16. "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Henderson, G.B., Ulrich, P., Fairlamb, A.H., Rosenberg, I., Pereira, M., Sela, M., Cerami, A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  17. Autoimmunity in chagas disease cardiomyopathy: Fulfilling the criteria at last? Kalil, J., Cunha-Neto, E. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  18. Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease. Gazzinelli, R.T., Leme, V.M., Cancado, J.R., Gazzinelli, G., Scharfstein, J. Infect. Immun. (1990) [Pubmed]
  19. Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Ribeirão, M., Pereira-Chioccola, V.L., Eichinger, D., Rodrigues, M.M., Schenkman, S. Glycobiology (1997) [Pubmed]
  20. Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi. Gonzalez, N.S., Cazzulo, J.J. Biochem. Pharmacol. (1989) [Pubmed]
  21. Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi. Allen, T.E., Ullman, B. Mol. Biochem. Parasitol. (1994) [Pubmed]
  22. Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. Gironès, N., Rodríguez, C.I., Carrasco-Marín, E., Hernáez, R.F., de Rego, J.L., Fresno, M. J. Clin. Invest. (2001) [Pubmed]
  23. IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18. Müller, U., Köhler, G., Mossmann, H., Schaub, G.A., Alber, G., Di Santo, J.P., Brombacher, F., Hölscher, C. J. Immunol. (2001) [Pubmed]
  24. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. Tarleton, R.L. J. Immunol. (1988) [Pubmed]
  25. Limited myocardial contractile reserve and chronotropic incompetence in patients with chronic Chagas' disease: assessment by dobutamine stress echocardiography. Acquatella, H., Pérez, J.E., Condado, J.A., Sánchez, I. J. Am. Coll. Cardiol. (1999) [Pubmed]
  26. Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity. Souza, P.E., Rocha, M.O., Rocha-Vieira, E., Menezes, C.A., Chaves, A.C., Gollob, K.J., Dutra, W.O. Infect. Immun. (2004) [Pubmed]
  27. Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease. Talvani, A., Rocha, M.O., Ribeiro, A.L., Correa-Oliveira, R., Teixeira, M.M. J. Infect. Dis. (2004) [Pubmed]
  28. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection. Abel, L.C., Rizzo, L.V., Ianni, B., Albuquerque, F., Bacal, F., Carrara, D., Bocchi, E.A., Teixeira, H.C., Mady, C., Kalil, J., Cunha-Neto, E. J. Autoimmun. (2001) [Pubmed]
  29. Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10. Moreno, M., Silva, E.L., Ramírez, L.E., Palacio, L.G., Rivera, D., Arcos-Burgos, M. Tissue Antigens (2004) [Pubmed]
  30. Atrophy of mesenteric lymph nodes in experimental Chagas' disease: differential role of Fas/Fas-L and TNFRI/TNF pathways. de Meis, J., Mendes-da-Cruz, D.A., Farias-de-Oliveira, D.A., Corrêa-de-Santana, E., Pinto-Mariz, F., Cotta-de-Almeida, V., Bonomo, A., Savino, W. Microbes Infect. (2006) [Pubmed]
  31. Trypanosoma cruzi: acute infection affects expression of alpha-2-macroglobulin and A2MR/LRP receptor differently in C3H and C57BL/6 mice. Soeiro, M.d.e. .N., Paiva, M.M., Waghabi, M.C., Meirelles, M.d.e. .N., Lorent, K., Henriques-Pons, A., Coutinho, C.M., Van Leuven, F., Araújo-Jorge, T.C. Exp. Parasitol. (2000) [Pubmed]
  32. Trypanosoma cruzi: characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and bloodstream trypomastigotes. Scharfstein, J., Schechter, M., Senna, M., Peralta, J.M., Mendonça-Previato, L., Miles, M.A. J. Immunol. (1986) [Pubmed]
  33. Mechanisms underlying immunosuppression induced by Trypanosoma cruzi. Kierszenbaum, F., Sztein, M.B. Parasitol. Today (Regul. Ed.) (1990) [Pubmed]
  34. Major Trypanosoma cruzi antigenic determinant in Chagas' heart disease shares homology with the systemic lupus erythematosus ribosomal P protein epitope. Mesri, E.A., Levitus, G., Hontebeyrie-Joskowicz, M., Dighiero, G., Van Regenmortel, M.H., Levin, M.J. J. Clin. Microbiol. (1990) [Pubmed]
  35. The metabolism and mode of action of gentian violet. Docampo, R., Moreno, S.N. Drug Metab. Rev. (1990) [Pubmed]
  36. Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease. Barcán, L., Luna, C., Lunaó, C., Clara, L., Sinagra, A., Valledor, A., De Rissio, A.M., De Rissioí, A.M., Gadano, A., Gadanoá, A., García, M.M., de Santibañes, E., Riarte, A. Liver Transpl. (2005) [Pubmed]
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