Interaction of apoA-II from human high density lipoprotein with lysolecithin.
The effects of lysolecithin and hexadecyltrimethylammonium bromide on the structure and stability of apoA-II from human high density lipoprotein have been evalued by circular dichroism and fluorescence measurements. There is a profound enhancement in the stability of apoA-II to guanidinium hydrochloride denaturation when it forms a phospholipid complex with lysolecithin micelles. This complex is not only resistant to guanidinium hydrochloride denaturation, but it can be formed in a 6 M solution of this denaturant. The behavior of apoA-II in the native human high density protein is much closer to that of the lysolecithin apoA-II complex than to that of the free apoA-II.[1]References
- Interaction of apoA-II from human high density lipoprotein with lysolecithin. Palumbo, G., Edelhoch, H. J. Biol. Chem. (1977) [Pubmed]
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