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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Micelles

  • Based on past attempts at developing vaccines against retroviruses, the most feasible configuration will be the glycoprotein linked to its transmembrane protein and assembled into micelles or rosettes by hydrophobic bonding [1].
  • With the aim of preparing a light-insensitive bacteriorhodopsin-like pigment, bacterio-opsin expressed in Escherichia coli was treated in phospholipid-detergent micelles with the retinal analog II, in which the C13-C14 trans-double bond cannot isomerize due to inclusion in a cyclopentene ring [2].
  • Retinol-induced rabbit erythrocyte hemolysis has been found not to be caused by the oxidative disruption of erythrocyte membrane lipids initiated by retinol oxidation, but rather to arise from physical damage of the membrane micelle induced by penetration of retinol molecules [3].
  • NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries [4].
  • Studies using defective interfering virus particles, UV light-inactivated virus, and purified micelles of the viral glycoprotein indicated that infectious virus was not required for sensitization of target cells for immune recognition by the class II MHC-restricted CTL clones [5].

High impact information on Micelles

  • The three-dimensional structure of the lipase-procolipase complex, co-crystallized with mixed micelles of phosphatidylcholine and bile salt, has been determined at 3 A resolution by X-ray crystallography [6].
  • Results presented here demonstrate that a mixture of fatty acid and lysophosphatidylcholine forms a bilayer type of organisation even though the individual components form micelles when dispersed in an aqueous phase [7].
  • The present study is a direct demonstration of Ca2+-induced release of Ca2+ from the SR of skinned cardiac cells treated with chlorotetracycline (CTC), a fluorescent chelate probe which enables changes in the amount of Ca2+ bound to a variety of biological membranes or micelles to be monitored [8].
  • Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles [9].
  • The molar ratio of the complex of profilin with PIP2 is 1:7 in micelles of pure PIP2 and 1:5 in bilayers composed largely of other phospholipids [10].

Chemical compound and disease context of Micelles


Biological context of Micelles


Anatomical context of Micelles

  • Endotoxin exocytosed by Kupffer cells fractionated into two peaks, one with a smaller and one with a larger apparent micelle size than native endotoxin but both smaller than the retained lipopolysaccharide [21].
  • Here we describe a soluble phospholipase A1 from bovine testis that preferentially hydrolyzes phosphatidic acid when assayed in Triton X-100 micelles [22].
  • The uptake of cholesterol delivered by mixed micelles by confluent CaCo-2 cells was partially inhibited by Ezetimibe and nonabsorbable Ezetimibe analogues [23].
  • Solubilization of egg yolk PC occurs in Na-trichloroacetate between 2 and 3 M and in Na-tribromoacetate between 1.5 and 2 M. The resulting optically clear solutions were found by gel exclusion chromatography to consist of micelles containing of the order of 10(2) lipid molecules which, according to 31P NMR, are undergoing rapid, isotropic motion [24].
  • These data suggest that a peptide (3,000 to 19,000) in the larger subunit of gamma-glutamyltranspeptidase is responsible for its binding to Triton micelles and probably for holding the enzyme in the brush border membrane [25].

Associations of Micelles with chemical compounds

  • Profilin isolated from platelets binds with high affinity to small clusters of phosphatidylinositol 4,5-bisphosphate (PIP2) molecules in micelles and also in bilayers with other phospholipids [10].
  • After extraction with deoxycholate (DOC), C5b-7 has a sedimentation velocity of 36S which further suggests the occurrence of C5b-7 in the form of tetrameric protein micelles [26].
  • Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone [27].
  • Gel filtration and sucrose gradient sedimentation showed sLFA-3 to be a single highly glycosylated polypeptide chain in solution, while mLFA-3 formed micelles of 8 LFA-3 monomers [28].
  • We have recently shown that lipopolysaccharide (LPS)-binding protein (LBP) is a lipid transfer protein that catalyzes two distinct reactions: movement of bacterial LPS (endotoxin) from LPS micelles to soluble CD14 (sCD14) and movement of LPS from micelles to reconstituted high density lipoprotein (R-HDL) particles [29].

Gene context of Micelles


Analytical, diagnostic and therapeutic context of Micelles

  • GTPase experiments with varying concentrations of p21 and constant concentrations of GAP and lipids indicate that the binding of GAP by the lipid micelles is responsible for the inhibition, a finding which was confirmed by fluorescence titrations and gel filtrations which show that the C-terminal domain of GAP is bound by lipid micelles [35].
  • In model bile, cholesterol crystallization was preceded by the appearance of the following distinct microstructures: spheroidal micelles (3-5 nm), discoidal membrane patches (50-150 nm) often in multiple layers (2-10), discs (50-100 nm), and unilamellar (50-200 nm) and larger multilamellar vesicles (MLVs) [36].
  • We have developed a novel drug delivery system that releases drug from stabilized micelles upon application of low-frequency ultrasound and that demonstrates efficacy using doxorubicin (Dox) to treat tumors in vivo [37].
  • Circular dichroism spectroscopy performed in the membrane-mimetic medium of deoxycholate micelles indicated comparable alpha-helical contents of mutants I32V and A27T to wild-type protein [38].
  • Enzyme kinetics using vesicles as well as optical titration using a micelle system with the detergent Tween 20 demonstrate that activation is correlated with the fraction of P450SCC in the high spin form [39].


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  2. A bacteriorhodopsin analog reconstituted with a nonisomerizable 13-trans retinal derivative displays light insensitivity. Bhattacharya, S., Marti, T., Otto, H., Heyn, M.P., Khorana, H.G. J. Biol. Chem. (1992) [Pubmed]
  3. Vitamin E: inhibition of retinol-induced hemolysis and membrane-stabilizing behavior. Urano, S., Inomori, Y., Sugawara, T., Kato, Y., Kitahara, M., Hasegawa, Y., Matsuo, M., Mukai, K. J. Biol. Chem. (1992) [Pubmed]
  4. NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries. Tinoco, L.W., Da Silva, A., Leite, A., Valente, A.P., Almeida, F.C. J. Biol. Chem. (2002) [Pubmed]
  5. Cytolytic T lymphocytes from the BALB/c-H-2dm2 mouse recognize the vesicular stomatitis virus glycoprotein and are restricted by class II MHC antigens. Browning, M.J., Huang, A.S., Reiss, C.S. J. Immunol. (1990) [Pubmed]
  6. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. van Tilbeurgh, H., Egloff, M.P., Martinez, C., Rugani, N., Verger, R., Cambillau, C. Nature (1993) [Pubmed]
  7. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers. Jain, M.K., van Echteld, C.J., Ramirez, F., de Gier, J., de Haas, G.H., van Deenen, L.L. Nature (1980) [Pubmed]
  8. Use of chlorotetracycline fluorescence to demonstrate Ca2+-induced release of Ca2+ from the sarcoplasmic reticulum of skinned cardiac cells. Fabiato, A., Fabiato, F. Nature (1979) [Pubmed]
  9. Structural mechanism of endosome docking by the FYVE domain. Kutateladze, T., Overduin, M. Science (2001) [Pubmed]
  10. The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Goldschmidt-Clermont, P.J., Machesky, L.M., Baldassare, J.J., Pollard, T.D. Science (1990) [Pubmed]
  11. Interaction of vesicular stomatitis virus with lipid vesicles: depletion of cholesterol and effect on virion membrane fluidity and infectivity. Moore, N.F., Patzer, E.J., Shaw, J.M., Thompson, T.E., Wagner, R.R. J. Virol. (1978) [Pubmed]
  12. Location of M13 coat protein in sodium dodecyl sulfate micelles as determined by NMR. Papavoine, C.H., Konings, R.N., Hilbers, C.W., van de Ven, F.J. Biochemistry (1994) [Pubmed]
  13. Vaccinia virus expresses a novel profilin with a higher affinity for polyphosphoinositides than actin. Machesky, L.M., Cole, N.B., Moss, B., Pollard, T.D. Biochemistry (1994) [Pubmed]
  14. The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles. Schibli, D.J., Montelaro, R.C., Vogel, H.J. Biochemistry (2001) [Pubmed]
  15. Amphotericin B incorporated into egg lecithin-bile salt mixed micelles: molecular and cellular aspects relevant to therapeutic efficacy in experimental mycoses. Brajtburg, J., Elberg, S., Kobayashi, G.S., Bolard, J. Antimicrob. Agents Chemother. (1994) [Pubmed]
  16. Watching fat digestion. Patton, J.S., Carey, M.C. Science (1979) [Pubmed]
  17. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Chapman, R.S., Lourenco, P.C., Tonner, E., Flint, D.J., Selbert, S., Takeda, K., Akira, S., Clarke, A.R., Watson, C.J. Genes Dev. (1999) [Pubmed]
  18. Kinetics of nitrosamine formation in the presence of micelle-forming surfactants. Okun, J.D., Archer, M.C. J. Natl. Cancer Inst. (1977) [Pubmed]
  19. Monoclonal immunoglobulin M lambda coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant. Thiagarajan, P., Shapiro, S.S., De Marco, L. J. Clin. Invest. (1980) [Pubmed]
  20. Structural studies of the lipid components of bile. Shipley, G.G. Hepatology (1990) [Pubmed]
  21. Clearance of gut-derived endotoxins by the liver. Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells. Fox, E.S., Thomas, P., Broitman, S.A. Gastroenterology (1989) [Pubmed]
  22. Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis. Higgs, H.N., Glomset, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  23. Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. Kramer, W., Girbig, F., Corsiero, D., Pfenninger, A., Frick, W., Jähne, G., Rhein, M., Wendler, W., Lottspeich, F., Hochleitner, E.O., Orsó, E., Schmitz, G. J. Biol. Chem. (2005) [Pubmed]
  24. Solubilization of phospholipids by chaotropic ion solutions. Oku, N., MacDonald, R.C. J. Biol. Chem. (1983) [Pubmed]
  25. Comparison of the size and physical properties of gamma-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with Triton X-100. Hughey, R.P., Curthoys, N. J. Biol. Chem. (1976) [Pubmed]
  26. Membrane attack complex of complement: a structural analysis of its assembly. Podack, E.R., Esser, A.F., Biesecker, G., Müller-Eberhard, H.J. J. Exp. Med. (1980) [Pubmed]
  27. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. Matsuura, E., Igarashi, Y., Yasuda, T., Triplett, D.A., Koike, T. J. Exp. Med. (1994) [Pubmed]
  28. Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3. Dustin, M.L., Olive, D., Springer, T.A. J. Exp. Med. (1989) [Pubmed]
  29. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. Wurfel, M.M., Hailman, E., Wright, S.D. J. Exp. Med. (1995) [Pubmed]
  30. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. Higgs, H.N., Pollard, T.D. J. Cell Biol. (2000) [Pubmed]
  31. Sarcolipin, the shorter homologue of phospholamban, forms oligomeric structures in detergent micelles and in liposomes. Hellstern, S., Pegoraro, S., Karim, C.B., Lustig, A., Thomas, D.D., Moroder, L., Engel, J. J. Biol. Chem. (2001) [Pubmed]
  32. Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2. Hulkower, K.I., Wertheimer, S.J., Levin, W., Coffey, J.W., Anderson, C.M., Chen, T., DeWitt, D.L., Crowl, R.M., Hope, W.C., Morgan, D.W. Arthritis Rheum. (1994) [Pubmed]
  33. Ligand selectivity and affinity of chemokine receptor CXCR1. Role of N-terminal domain. Rajagopalan, L., Rajarathnam, K. J. Biol. Chem. (2004) [Pubmed]
  34. Functional interaction of ADP-ribosylation factor 1 with phosphatidylinositol 4,5-bisphosphate. Randazzo, P.A. J. Biol. Chem. (1997) [Pubmed]
  35. The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures. Serth, J., Lautwein, A., Frech, M., Wittinghofer, A., Pingoud, A. EMBO J. (1991) [Pubmed]
  36. Microstructural evolution of lipid aggregates in nucleating model and human biles visualized by cryogenic transmission electron microscopy. Konikoff, F.M., Danino, D., Weihs, D., Rubin, M., Talmon, Y. Hepatology (2000) [Pubmed]
  37. Ultrasonically activated chemotherapeutic drug delivery in a rat model. Nelson, J.L., Roeder, B.L., Carmen, J.C., Roloff, F., Pitt, W.G. Cancer Res. (2002) [Pubmed]
  38. Transmembrane region of wild-type and mutant M13 coat proteins. Conformational role of beta-branched residues. Deber, C.M., Li, Z., Joensson, C., Glibowicka, M., Xu, G.Y. J. Biol. Chem. (1992) [Pubmed]
  39. Branched phosphatidylcholines stimulate activity of cytochrome P450SCC (CYP11A1) in phospholipid vesicles by enhancing cholesterol binding, membrane incorporation, and protein exchange. Kisselev, P., Wessel, R., Pisch, S., Bornscheuer, U., Schmid, R.D., Schwarz, D. J. Biol. Chem. (1998) [Pubmed]
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