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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Identification of 14-3-3epsilon substrates from embryonic murine brain.

Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol.[1]


  1. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif, B.A., Cao, Z., Schwartz, D., Carraway, K.L., Gygi, S.P. J. Proteome Res. (2006) [Pubmed]
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