Gene Review:
USP8 - ubiquitin specific peptidase 8
Homo sapiens
Synonyms:
Deubiquitinating enzyme 8, HumORF8, KIAA0055, SPG59, UBPY, ...
- Endocytosis: the DUB version. Clague, M.J., Urb??, S. Trends Cell Biol. (2006)
- UBPY: a growth-regulated human ubiquitin isopeptidase. Naviglio, S., Mattecucci, C., Matoskova, B., Nagase, T., Nomura, N., Di Fiore, P.P., Draetta, G.F. EMBO J. (1998)
- Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Wu, X., Yen, L., Irwin, L., Sweeney, C., Carraway, K.L. Mol. Cell. Biol. (2004)
- Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8). Avvakumov, G.V., Walker, J.R., Xue, S., Finerty, P.J., Mackenzie, F., Newman, E.M., Dhe-Paganon, S. J. Biol. Chem. (2006)
- Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif, B.A., Cao, Z., Schwartz, D., Carraway, K.L., Gygi, S.P. J. Proteome Res. (2006)
- Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. Gnesutta, N., Ceriani, M., Innocenti, M., Mauri, I., Zippel, R., Sturani, E., Borgonovo, B., Berruti, G., Martegani, E. J. Biol. Chem. (2001)
- A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. Kato, M., Miyazawa, K., Kitamura, N. J. Biol. Chem. (2000)
- The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation. Row, P.E., Prior, I.A., McCullough, J., Clague, M.J., Urbé, S. J. Biol. Chem. (2006)
- A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Mizuno, E., Kobayashi, K., Yamamoto, A., Kitamura, N., Komada, M. Traffic (2006)
- The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. Row, P.E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., Clague, M.J., Sanderson, C.M., Urbé, S. J. Biol. Chem. (2007)