- Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. Nakahira, K., Kim, H.P., Geng, X.H., Nakao, A., Wang, X., Murase, N., Drain, P.F., Wang, X., Sasidhar, M., Nabel, E.G., Takahashi, T., Lukacs, N.W., Ryter, S.W., Morita, K., Choi, A.M. J. Exp. Med. (2006)