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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Urinary Bactericidal Activity of Oral Antibiotics against Common Urinary Tract Pathogens in an ex vivo Model.

Background: In this investigation, the urine samples obtained in a single oral-dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant urinary tract pathogens. Methods: Six healthy volunteers received a single oral dose of ten oral antibiotics available in Croatia. Urine samples were taken every 2 h during the whole dosing interval of the particular antibiotic. The urinary bactericidal activity was tested by determination of urinary bactericidal titers. Results: All antibiotics showed a significant urinary bactericidal activity against non-extended spectrum beta-lactamase Escherichia coli and Proteus mirabilis. Fluoroquinolones displayed high and persisting levels of urinary bactericidal activity against all gram-negative bacteria and Staphylococcus saprophyticus. Conclusions: Average urinary bactericidal activity can be predicted from in vitro susceptibility testing, but we expect that there will be patients with a low level of urinary bactericidal activity. Copyright (c) 2006 S. Karger AG, Basel.[1]

References

  1. Urinary Bactericidal Activity of Oral Antibiotics against Common Urinary Tract Pathogens in an ex vivo Model. Bedenic, B., Topic, M., Budimir, A., Bubonja, M. Chemotherapy. (2006) [Pubmed]
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