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Disease relevance of Proteus


High impact information on Proteus


Chemical compound and disease context of Proteus

  • One component of a factor in Proteus mirabilis (Factor 1) which specifically amplifies the induction of several liver enzymes by glucocorticoid in target cells also increases the growth inhibition of glucocorticoid on the ascitic form of L1210 cells and solid tumors of L5178Y lymphoblasts in vivo [11].
  • The structure of the colony migration factor from pathogenic Proteus mirabilis. A capsular polysaccharide that facilitates swarming [12].
  • Purification and properties of the alpha2beta2 complex of tryptophan synthetase of Proteus mirabilis [13].
  • Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii [14].
  • Isolation and characterization of crystalline methylglyoxal synthetase from Proteus vulgaris [15].

Biological context of Proteus


Anatomical context of Proteus


Gene context of Proteus

  • Cloned into Escherichia coli the recB, recC and recD genes of Proteus mirabilis produce a recBCD enzyme (exoV) functional in recombination and DNA repair [24].
  • FK482 was not hydrolyzed by the TEM-1 and TEM-2 beta-lactamases but was hydrolyzed by TEM-3 and the Proteus vulgaris enzyme [25].
  • A hexamer sequence of proteus haemolysin spanning residues 32-37 (ESRRAL) has been identified which resembles biochemically, and discriminates by charge, between HLA types associated with RA (DR1, Dw4, Dw14, Dw15), and those not linked with the disease (Dw10, Dw13) [26].
  • To characterize the PldA protein further, the pldA genes of Salmonella typhimurium, Klebsiella pneumoniae, and Proteus vulgaris were cloned and sequenced [27].
  • The data suggest that IGF production is generally disturbed in Proteus syndrome with imbalanced levels of specific IGFBP in affected tissue [28].

Analytical, diagnostic and therapeutic context of Proteus


  1. Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins. Acar, J.F., Sabath, L.D., Ruch, P.A. J. Clin. Invest. (1975) [Pubmed]
  2. Five-year surveillance of aminoglycoside usage in a university hospital. Betts, R.F., Valenti, W.M., Chapman, S.W., Chonmaitree, T., Mowrer, G., Pincus, P., Messner, M., Robertson, R. Ann. Intern. Med. (1984) [Pubmed]
  3. The incorporation of glucosamine into enterobacterial core lipopolysaccharide: two enzymatic steps are required. Regué, M., Izquierdo, L., Fresno, S., Jimenez, N., Piqué, N., Corsaro, M.M., Parrilli, M., Naldi, T., Merino, S., Tomás, J.M. J. Biol. Chem. (2005) [Pubmed]
  4. The etiology of urinary tract infection: traditional and emerging pathogens. Ronald, A. Am. J. Med. (2002) [Pubmed]
  5. Treatment of pediatric infections with amikacin as first-line aminoglycoside. Shulman, S.T., Yogev, R. Am. J. Med. (1985) [Pubmed]
  6. Endocytotic sucrose uptake in Amoeba proteus induced with the calcium ionophore A23187. Prusch, R.D. Science (1980) [Pubmed]
  7. PTEN mutations and proteus syndrome. Biesecker, L.G., Rosenberg, M.J., Vacha, S., Turner, J.T., Cohen, M.M. Lancet (2001) [Pubmed]
  8. Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Nilsson, K., Lindquist, O., Påhlson, C. Lancet (1999) [Pubmed]
  9. Antibodies to proteus in rheumatoid arthritis. Ebringer, A., Ptaszynska, T., Corbett, M., Wilson, C., Macafee, Y., Avakian, H., Baron, P., James, D.C. Lancet (1985) [Pubmed]
  10. A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters. Greener, T., Govezensky, D., Zamir, A. EMBO J. (1993) [Pubmed]
  11. Amplification of growth inhibition by glucocorticoid on L5178Y and L1210 lymphoblasts in vivo. Kido, H., Tomihara, Y., Watanabe, I., Ohsawa, N., Katunuma, N. Cancer Res. (1979) [Pubmed]
  12. The structure of the colony migration factor from pathogenic Proteus mirabilis. A capsular polysaccharide that facilitates swarming. Rahman, M.M., Guard-Petter, J., Asokan, K., Hughes, C., Carlson, R.W. J. Biol. Chem. (1999) [Pubmed]
  13. Purification and properties of the alpha2beta2 complex of tryptophan synthetase of Proteus mirabilis. Riverin, M., Drapeau, G.R. J. Biol. Chem. (1976) [Pubmed]
  14. Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii. Claflin, J.L., George, J., Dell, C., Berry, J. J. Immunol. (1989) [Pubmed]
  15. Isolation and characterization of crystalline methylglyoxal synthetase from Proteus vulgaris. Tsai, P.K., Gracy, R.W. J. Biol. Chem. (1976) [Pubmed]
  16. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Waite, K.A., Eng, C. Hum. Mol. Genet. (2003) [Pubmed]
  17. Characterization of the tryptophanase operon of Proteus vulgaris. Cloning, nucleotide sequence, amino acid homology, and in vitro synthesis of the leader peptide and regulatory analysis. Kamath, A.V., Yanofsky, C. J. Biol. Chem. (1992) [Pubmed]
  18. Molecular cloning and site-directed mutagenesis of glutathione S-transferase from Escherichia coli. The conserved tyrosyl residue near the N terminus is not essential for catalysis. Nishida, M., Kong, K.H., Inoue, H., Takahashi, K. J. Biol. Chem. (1994) [Pubmed]
  19. A spectrin-like protein present on membranes of Amoeba proteus as studied with monoclonal antibodies. Choi, E.Y., Jeon, K.W. Exp. Cell Res. (1989) [Pubmed]
  20. Unique ability of the Proteus mirabilis capsule to enhance mineral growth in infectious urinary calculi. Dumanski, A.J., Hedelin, H., Edin-Liljegren, A., Beauchemin, D., McLean, R.J. Infect. Immun. (1994) [Pubmed]
  21. Modulation of effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis as measured in a chemiluminescence assay. Weber, G., Heck, D., Bartlett, R.R., Nixdorff, K. Infect. Immun. (1992) [Pubmed]
  22. Antibody-producing cell responses to an isolated outer membrane protein and to complexes of this antigen with lipopolysaccharide or with vesicles of phospholipids from Proteus mirabilis. Karch, H., Nixdorff, K. Infect. Immun. (1981) [Pubmed]
  23. Trimethoprim-sulfamethoxazole in cyst fluid from autosomal dominant polycystic kidneys. Elzinga, L.W., Golper, T.A., Rashad, A.L., Carr, M.E., Bennett, W.M. Kidney Int. (1987) [Pubmed]
  24. Functional analyses of Proteus mirabilis wild-type and mutant RecBCD enzymes in Escherichia coli reveal a new mutant phenotype. Weichenhan, D., Wackernagel, W. Mol. Microbiol. (1989) [Pubmed]
  25. Comparative in vitro activity and beta-lactamase stability of FK482, a new oral cephalosporin. Neu, H.C., Saha, G., Chin, N.X. Antimicrob. Agents Chemother. (1989) [Pubmed]
  26. Sequence similarity between HLA-DR1 and DR4 subtypes associated with rheumatoid arthritis and proteus/serratia membrane haemolysins. Ebringer, A., Cunningham, P., Ahmadi, K., Wrigglesworth, J., Hosseini, R., Wilson, C. Ann. Rheum. Dis. (1992) [Pubmed]
  27. Molecular characterization of enterobacterial pldA genes encoding outer membrane phospholipase A. Brok, R.G., Brinkman, E., van Boxtel, R., Bekkers, A.C., Verheij, H.M., Tommassen, J. J. Bacteriol. (1994) [Pubmed]
  28. Growth hormone (GH), insulin-like growth factors (IGFs), and IGF-binding protein-3 (IGFBP-3) in a child with Proteus syndrome. Rudolph, G., Blum, W.F., Jenne, E.W., Schöning, M., Enders, H., Meitinger, T., Murken, J.D., Kampik, A. Am. J. Med. Genet. (1994) [Pubmed]
  29. Chemical properties of lipopolysaccharides from spotted fever group rickettsiae and their common antigenicity with lipopolysaccharides from Proteus species. Amano, K., Fujita, M., Suto, T. Infect. Immun. (1993) [Pubmed]
  30. Identification of a novel plasmid-encoded dihydrofolate reductase mediating high-level resistance to trimethoprim. Wylie, B.A., Amyes, S.G., Young, H.K., Koornhof, H.J. J. Antimicrob. Chemother. (1988) [Pubmed]
  31. Ureaplasma urealyticum-induced crystallization of magnesium ammonium phosphate and calcium phosphates in synthetic urine. Grenabo, L., Brorson, J.E., Hedelin, H., Pettersson, S. J. Urol. (1984) [Pubmed]
  32. Production and characterization of a monoclonal antibody to the O-acetylated peptidoglycan of Proteus mirabilis. Gyorffy, S., Clarke, A.J. J. Bacteriol. (1992) [Pubmed]
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