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Gene Review

SCGB1A1  -  secretoglobin, family 1A, member 1...

Homo sapiens

Synonyms: CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, ...
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Disease relevance of SCGB1A1

  • The G38A polymorphism in the CC10 gene may influence protein expression and be associated with the development of progressive sarcoidosis [1].
  • MATERIALS AND METHODS: Urinary parameters in relation to urolithiasis of normal subjects and recurrent stone formers were measured [2].
  • CC16 38A also displayed a positive linear trend with atopic dermatitis [3].
  • MATERIALS AND METHODS: Urine samples collected from 40 patients with bladder cancers, 32 healthy volunteers, and 7 old volunteers with benign prostate hypertrophy were treated with gelatin-beads as a group-specific affinity carrier [4].
  • Overexpression of CC10 modifies neoplastic potential in lung cancer cells [5].

Psychiatry related information on SCGB1A1

  • Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders [6].
  • METHODS: Urinary excretion of cortisol and its principal conjugated metabolites was studied in ten women with mild to moderate Alzheimer's disease, seven healthy elderly women and seven young women [7].
  • RESULTS: Serum IL-6 and sIL-6R, but not sgp130, sIL-RA, CC16, or sCD8, concentrations were significantly higher in PTSD patients than in normal volunteers [8].
  • MATERIALS AND METHODS: Urine was collected for 24-hour periods from 44 children with monosymptomatic nocturnal enuresis, 10 children with other forms of enuresis/incontinence (nonmonosymptomatic nocturnal enuresis) and 25 controls, and its aMT6s concentration was estimated using a commercially available radioimmunoassay [9].
  • METHODS AND MATERIALS: Urinary incontinence after (125)I prostate brachytherapy was evaluated using a patient self-assessment questionnaire based on the NCI Common Toxicity Criteria (version 2) [10].

High impact information on SCGB1A1


Chemical compound and disease context of SCGB1A1


Biological context of SCGB1A1


Anatomical context of SCGB1A1

  • Binding to cubilin results in uptake and lysosomal degradation of CCSP in cultured cells [26].
  • Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines [23].
  • CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties [24].
  • Clara cell 10 kD protein (CC10) is expressed specifically in a portion of nonciliated airway epithelial cells [27].
  • By contrast, sputum CC16 did not change significantly in either condition, although it was positively correlated with UGRP1 in patients and control subjects [28].

Associations of SCGB1A1 with chemical compounds


Physical interactions of SCGB1A1


Regulatory relationships of SCGB1A1

  • CONCLUSIONS: Urinary excretion of 6 beta-hydroxycortisol may be useful as a screening tool in early-phase development to assess the potential for an investigational drug to induce CYP3A [37].
  • METHODS: Urinary Cys-LTs were measured by direct enzyme immunoassay in 17 adult patients with AEDS and in 17 healthy controls in whom atopy had been excluded [38].
  • Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown [39].

Other interactions of SCGB1A1

  • Subjects with CD14 -159CC and CC16 38AA were more likely to have moderate or severe acute asthma [40].
  • Therefore, potential links between CC16 A38G, asthma and atopy were investigated in an unselected population of young adult Danes [3].
  • CONCLUSIONS: Urinary prokallikrein and PLUNC may be the new biomarkers which play a role in inflammation and immune response of OLP [41].
  • CONCLUSIONS: Urinary excretion of MMP-2 and MMP-9 is associated with a high stage and grade of bladder cancer, and they may serve as indicators of tumor progression and recurrence in the future [42].
  • Rationale: Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16), members of the secretoglobin family, increasingly appear to play a role in airway inflammatory response [28].

Analytical, diagnostic and therapeutic context of SCGB1A1


  1. Polymorphism of Clara cell 10-kD protein gene of sarcoidosis. Ohchi, T., Shijubo, N., Kawabata, I., Ichimiya, S., Inomata, S., Yamaguchi, A., Umemori, Y., Itoh, Y., Abe, S., Hiraga, Y., Sato, N. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  2. Comparison of fibronectin content in urinary macromolecules between normal subjects and recurrent stone formers. Tsujihata, M., Miyake, O., Yoshimura, K., Kakimoto, K., Takahara, S., Okuyama, A. Eur. Urol. (2001) [Pubmed]
  3. Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes. Candelaria, P.V., Backer, V., Laing, I.A., Porsbjerg, C., Nepper-Christensen, S., de Klerk, N., Goldblatt, J., Le Souëf, P.N. Immunogenetics (2005) [Pubmed]
  4. Proteome analysis of gelatin-bound urinary proteins from patients with bladder cancers. Saito, M., Kimoto, M., Araki, T., Shimada, Y., Fujii, R., Oofusa, K., Hide, M., Usui, T., Yoshizato, K. Eur. Urol. (2005) [Pubmed]
  5. Overexpression of CC10 modifies neoplastic potential in lung cancer cells. Szabo, E., Goheer, A., Witschi, H., Linnoila, R.I. Cell Growth Differ. (1998) [Pubmed]
  6. Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders. Schatzberg, A.F., Samson, J.A., Bloomingdale, K.L., Orsulak, P.J., Gerson, B., Kizuka, P.P., Cole, J.O., Schildkraut, J.J. Arch. Gen. Psychiatry (1989) [Pubmed]
  7. Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease. Rasmuson, S., Andrew, R., Näsman, B., Seckl, J.R., Walker, B.R., Olsson, T. Biol. Psychiatry (2001) [Pubmed]
  8. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Maes, M., Lin, A.H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., Bosmans, E. Biol. Psychiatry (1999) [Pubmed]
  9. Melatonin production is similar in children with monosymptomatic nocturnal enuresis or other forms of enuresis/incontinence and in controls. Kirchlechner, V., Hoffmann-Ehrhart, B., Kovacs, J., Waldhauser, F. J. Urol. (2001) [Pubmed]
  10. Factors predicting for urinary incontinence after prostate brachytherapy. McElveen, T.L., Waterman, F.M., Kim, H., Dicker, A.P. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  11. Letter: Urinary muramidase in hairy-cell leukemia. Weisberg, J.I. N. Engl. J. Med. (1975) [Pubmed]
  12. Making optimum use of the microbiology laboratory. II. Urine, respiratory, wound, and cervicovaginal exudate. Bartlett, R.C. JAMA (1982) [Pubmed]
  13. Letter: Urinary retention as complication of levodopa therapy. Jotkowitz, S. JAMA (1976) [Pubmed]
  14. Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke. Anderson, K.E., Carmella, S.G., Ye, M., Bliss, R.L., Le, C., Murphy, L., Hecht, S.S. J. Natl. Cancer Inst. (2001) [Pubmed]
  15. Re: Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. Castagnetta, L.A., Carruba, G. J. Natl. Cancer Inst. (1999) [Pubmed]
  16. Angiotensin II related to sodium excretion modulates left ventricular structure in human essential hypertension. Schmieder, R.E., Langenfeld, M.R., Friedrich, A., Schobel, H.P., Gatzka, C.D., Weihprecht, H. Circulation (1996) [Pubmed]
  17. Urinary free cortisol in chronic fatigue syndrome. Cleare, A.J., Blair, D., Chambers, S., Wessely, S. The American journal of psychiatry. (2001) [Pubmed]
  18. Increased platelet activation in the chronic phase after cerebral ischemia and intracerebral hemorrhage. van Kooten, F., Ciabattoni, G., Koudstaal, P.J., Dippel, D.W., Patrono, C. Stroke (1999) [Pubmed]
  19. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Rosenbaum, M., Hirsch, J., Murphy, E., Leibel, R.L. Am. J. Clin. Nutr. (2000) [Pubmed]
  20. Neurochemical studies on tardive dyskinesia. II. Urinary methoxyhydroxyphenylglycol and plasma dopamine-beta-hydroxylase. Markianos, M., Tripodianakis, J., Garelis, E. Biol. Psychiatry (1983) [Pubmed]
  21. Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma. Saadat, M., Saadat, I., Saboori, Z., Emad, A. J. Allergy Clin. Immunol. (2004) [Pubmed]
  22. Quantitation of N-Acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-l-cysteine in Human Urine: Comparison with Glutathione-S-transferase Genotypes in Smokers. Upadhyaya, P., Rao, P., Hochalter, J.B., Li, Z.Z., Villalta, P.W., Hecht, S.S. Chem. Res. Toxicol. (2006) [Pubmed]
  23. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Wolf, M., Klug, J., Hackenberg, R., Gessler, M., Grzeschik, K.H., Beato, M., Suske, G. Hum. Mol. Genet. (1992) [Pubmed]
  24. Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children. Sengler, C., Heinzmann, A., Jerkic, S.P., Haider, A., Sommerfeld, C., Niggemann, B., Lau, S., Forster, J., Schuster, A., Kamin, W., Bauer, C., Laing, I., LeSouef, P., Wahn, U., Deichmann, K., Nickel, R. J. Allergy Clin. Immunol. (2003) [Pubmed]
  25. A polymorphism of the CC16 gene is associated with an increased risk of asthma. Laing, I.A., Goldblatt, J., Eber, E., Hayden, C.M., Rye, P.J., Gibson, N.A., Palmer, L.J., Burton, P.R., Le Souëf, P.N. J. Med. Genet. (1998) [Pubmed]
  26. A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. Burmeister, R., Boe, I.M., Nykjaer, A., Jacobsen, C., Moestrup, S.K., Verroust, P., Christensen, E.I., Lund, J., Willnow, T.E. J. Biol. Chem. (2001) [Pubmed]
  27. Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs). Navab, R., Wang, Y., Chow, Y.H., Wang, A., Jankov, R.P., Takamoto, N., Tsai, S.Y., Tsai, M.J., Tanswell, A.K., Hu, J. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  28. Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. de Burbure, C., Pignatti, P., Corradi, M., Malerba, M., Clippe, A., Dumont, X., Moscato, G., Mutti, A., Bernard, A. Chest (2007) [Pubmed]
  29. Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein. Okutani, R., Itoh, Y., Hirata, H., Kasahara, T., Mukaida, N., Kawai, T. J. Chromatogr. (1992) [Pubmed]
  30. Urinary free cortisol is not a biochemical marker of hypertension. Krall, P., Carvajal, C., Ortiz, E., Muñoz, C., Garrido, J.L., Mosso, L., Fardella, C. Am. J. Hypertens. (2007) [Pubmed]
  31. Evaluation of genetic damage in Brazilian footwear-workers: Biomarkers of exposure, effect, and susceptibility. Heuser, V.D., Erdtmann, B., Kvitko, K., Rohr, P., da Silva, J. Toxicology (2007) [Pubmed]
  32. Pneumotoxicity of dust from aluminum foundry and pure alumina: a comparative study of morphology and biomarkers in rats. Hałatek, T., Opalska, B., Lao, I., Stetkiewicz, J., Rydzyński, K. International journal of occupational medicine and environmental health. (2005) [Pubmed]
  33. Blood and Urinary nicotine in non-smokers. Russell, M.A., Feyerabend, C. Lancet (1975) [Pubmed]
  34. Changes in urine markers and symptoms after bladder distention for interstitial cystitis. Erickson, D.R., Kunselman, A.R., Bentley, C.M., Peters, K.M., Rovner, E.S., Demers, L.M., Wheeler, M.A., Keay, S.K. J. Urol. (2007) [Pubmed]
  35. Effect of pioglitazone on urinary liver-type fatty acid-binding protein concentrations in diabetes patients with microalbuminuria. Nakamura, T., Sugaya, T., Kawagoe, Y., Ueda, Y., Koide, H. Diabetes Metab. Res. Rev. (2006) [Pubmed]
  36. Hostility and Urine Norepinephrine Interact to Predict Insulin Resistance: The VA Normative Aging Study. Zhang, J., Niaura, R., Dyer, J.R., Shen, B.J., Todaro, J.F., McCaffery, J.M., Spiro, A., Ward, K.D. Psychosomatic medicine. (2006) [Pubmed]
  37. Urinary excretion of 6 beta-hydroxycortisol as an in vivo marker for CYP3A induction: applications and recommendations. Kovacs, S.J., Martin, D.E., Everitt, D.E., Patterson, S.D., Jorkasky, D.K. Clin. Pharmacol. Ther. (1998) [Pubmed]
  38. Urinary leukotriene levels are increased during exacerbation of atopic eczema/dermatitis syndrome. Relation to clinical status. Adamek-Guzik, T., Guzik, T.J., Czerniawska-Mysik, G., Korpanty, G., Mastalerz, L., Radwan, J., Szczeklik, A. Allergy (2002) [Pubmed]
  39. Application of alkaline phosphatases from different sources in pharmaceutical and clinical analysis for the determination of their cofactors; zinc and magnesium ions. Muginova, S.V., Zhavoronkova, A.M., Polyakov, A.E., Shekhovtsova, T.N. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2007) [Pubmed]
  40. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Martin, A.C., Laing, I.A., Khoo, S.K., Zhang, G., Rueter, K., Teoh, L., Taheri, S., Hayden, C.M., Geelhoed, G.C., Goldblatt, J., LeSouëf, P.N. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  41. Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus. Yang, L.L., Liu, X.Q., Liu, W., Cheng, B., Li, M.T. Inflamm. Res. (2006) [Pubmed]
  42. Excretion of matrix metalloproteinases 2 and 9 in urine is associated with a high stage and grade of bladder carcinoma. Gerhards, S., Jung, K., Koenig, F., Daniltchenko, D., Hauptmann, S., Schnorr, D., Loening, S.A. Urology (2001) [Pubmed]
  43. Serum CC-10 in inflammatory lung diseases. Ye, Q., Fujita, M., Ouchi, H., Inoshima, I., Maeyama, T., Kuwano, K., Horiuchi, Y., Hara, N., Nakanishi, Y. Respiration; international review of thoracic diseases. (2004) [Pubmed]
  44. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Hay, J.G., Danel, C., Chu, C.S., Crystal, R.G. Am. J. Physiol. (1995) [Pubmed]
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