Disease relevance of SCGB1A1

• The G38A polymorphism in the CC10 gene may influence protein expression and be associated with the development of progressive sarcoidosis [1].
• MATERIALS AND METHODS: Urinary parameters in relation to urolithiasis of normal subjects and recurrent stone formers were measured [2].
• CC16 38A also displayed a positive linear trend with atopic dermatitis [3].
• MATERIALS AND METHODS: Urine samples collected from 40 patients with bladder cancers, 32 healthy volunteers, and 7 old volunteers with benign prostate hypertrophy were treated with gelatin-beads as a group-specific affinity carrier [4].
• Overexpression of CC10 modifies neoplastic potential in lung cancer cells [5].

Psychiatry related information on SCGB1A1

• Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders [6].
• METHODS: Urinary excretion of cortisol and its principal conjugated metabolites was studied in ten women with mild to moderate Alzheimer's disease, seven healthy elderly women and seven young women [7].
• RESULTS: Serum IL-6 and sIL-6R, but not sgp130, sIL-RA, CC16, or sCD8, concentrations were significantly higher in PTSD patients than in normal volunteers [8].
• MATERIALS AND METHODS: Urine was collected for 24-hour periods from 44 children with monosymptomatic nocturnal enuresis, 10 children with other forms of enuresis/incontinence (nonmonosymptomatic nocturnal enuresis) and 25 controls, and its aMT6s concentration was estimated using a commercially available radioimmunoassay [9].
• METHODS AND MATERIALS: Urinary incontinence after (125)I prostate brachytherapy was evaluated using a patient self-assessment questionnaire based on the NCI Common Toxicity Criteria (version 2) [10].

High impact information on SCGB1A1

• Letter: Urinary muramidase in hairy-cell leukemia [11].
• Making optimum use of the microbiology laboratory. II. Urine, respiratory, wound, and cervicovaginal exudate [12].
• Letter: Urinary retention as complication of levodopa therapy [13].
• RESULTS: Urinary levels of nicotine, cotinine, NNAL, and NNAL-Gluc were statistically significantly higher in exposed women than in unexposed women [14].
• Re: Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women [15].

Chemical compound and disease context of SCGB1A1

• BACKGROUND: Urinary sodium excretion and angiotensin II (Ang II), which are linked in a physiological feedback mechanism, have both been described to be blood pressure-independent determinants of left ventricular hypertrophy in essential hypertension [16].
• RESULTS: Urinary free cortisol was significantly lower in the subjects with chronic fatigue syndrome regardless of the presence or absence of current or past comorbid psychiatric illness [17].
• RESULTS: Urinary 11-dehydro-TXB2 averaged 294+/-139, 413+/-419, and 557+/-432 pmol/mmol creatinine for patients with TIA, ischemic stroke, and intracerebral hemorrhage, respectively; the values were higher in all subgroups (P<0.01) than that in control patients (119+/-66 pmol/mmol) [18].
• RESULTS: Urinary norepinephrine excretion decreased significantly during and after weight loss and increased during and after weight gain [19].
• Neurochemical studies on tardive dyskinesia. II. Urinary methoxyhydroxyphenylglycol and plasma dopamine-beta-hydroxylase [20].

Biological context of SCGB1A1

• Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma [21].
• Quantitation of N-Acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-l-cysteine in Human Urine: Comparison with Glutathione-S-transferase Genotypes in Smokers [22].
• Comparison of the amino acid sequences showed that CC10 is homologous to rabbit uteroglobin [23].
• A single-nucleotide polymorphism (SNP) in the CC16 gene (A38G) was previously associated with asthma [24].
• Mutation detection methods identified an adenine to guanine substitution in the CC16 gene at position 38 (A38G) downstream from the transcription initiation site within the non-coding region of exon 1 [25].

Anatomical context of SCGB1A1

• Binding to cubilin results in uptake and lysosomal degradation of CCSP in cultured cells [26].
• Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines [23].
• CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties [24].
• Clara cell 10 kD protein (CC10) is expressed specifically in a portion of nonciliated airway epithelial cells [27].
• By contrast, sputum CC16 did not change significantly in either condition, although it was positively correlated with UGRP1 in patients and control subjects [28].

Associations of SCGB1A1 with chemical compounds

• The N-terminal amino acid residue of UP1 was found to be glutamic acid, contrary to what was reported previously [29].
• We obtained 24-h urine to measure urinary free cortisol (UFF) and creatinine (Cr) [30].
• As biomarker of exposure, we obtained data on hippuric acid (HA), the main metabolite of toluene in urine, and DNA damage detected by the Comet assay in blood cells [31].
• After 3, 6 and 9 months since instillation, the following biomarkers were assessed in lung tissues: Clara cell protein (CC16), hyaluronic acid (HA), total protein, metaloproteinases (MMP) in bronchoalveolar lavage fluid (BALF), and GSH-S-transferase (GST) [32].
• Blood and Urinary nicotine in non-smokers [33].

Physical interactions of SCGB1A1

• Using surface plasmon resonance analysis, we demonstrate that CCSP binds to cubilin, a peripheral membrane protein on the surface of proximal tubular cells [26].
• Bladder distention altered urine anti-proliferative factor activity and heparin-binding epidermal growth factor-like growth factor levels toward normal, but the mechanism of symptom relief after distention is still unknown [34].
• BACKGROUND: Urinary liver-type fatty acid-binding protein (L-FABP) is a useful marker for renal tubulointerstitial injury [35].
• Hostility and Urine Norepinephrine Interact to Predict Insulin Resistance: The VA Normative Aging Study [36].

Regulatory relationships of SCGB1A1

• CONCLUSIONS: Urinary excretion of 6 beta-hydroxycortisol may be useful as a screening tool in early-phase development to assess the potential for an investigational drug to induce CYP3A [37].
• METHODS: Urinary Cys-LTs were measured by direct enzyme immunoassay in 17 adult patients with AEDS and in 17 healthy controls in whom atopy had been excluded [38].
• Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown [39].

Other interactions of SCGB1A1

• Subjects with CD14 -159CC and CC16 38AA were more likely to have moderate or severe acute asthma [40].
• Therefore, potential links between CC16 A38G, asthma and atopy were investigated in an unselected population of young adult Danes [3].
• CONCLUSIONS: Urinary prokallikrein and PLUNC may be the new biomarkers which play a role in inflammation and immune response of OLP [41].
• CONCLUSIONS: Urinary excretion of MMP-2 and MMP-9 is associated with a high stage and grade of bladder cancer, and they may serve as indicators of tumor progression and recurrence in the future [42].
• Rationale: Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16), members of the secretoglobin family, increasingly appear to play a role in airway inflammatory response [28].

Analytical, diagnostic and therapeutic context of SCGB1A1

• Pure UP1 was obtained in a final yield of 60.2%, and observed as a single electrophoretic band and as a single peak on reversed-phase high-performance liquid chromatography [29].
• The A/A genotypes had significantly lower bronchoalveolar lavage fluid CC10 levels than the G/G (nonsmokers, p = 0.0054, and smokers, p = 0.0045) and G/A genotypes (nonsmokers, p = 0.0022, and smokers, p = 0.0402) [1].
• Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody [43].
• Quantification of CC10 gene expression in freshly isolated human proximal airway epithelial cells demonstrated very high mRNA levels, approximately fivefold greater than gamma-actin mRNA, and in situ hybridization localized CC10 mRNA to nonciliated airway epithelial cells [44].
• Sequence analysis demonstrated that the human CC10 gene is comprised of three short exons separated by a long first and short second intron, and with a 5' flanking region typical of a regulated gene [44].

References