Toxicity of spinal local anaesthetics.
Recent reports of severe neurological injury after spinal anaesthesia have generated concerns about the neurotoxic potential of local anaesthetics and, in particular, of lignocaine. Further, there is an increasing body of evidence indicating that transient neurological symptoms commonly occur after uneventful lignocaine spinal anaesthesia but not after bupivacaine. Results from an epidemiological study suggest that patient positioning and outpatient status are major co-factors. Neither the dose nor the concentration of lignocaine appear to reduce the risk for transient neurological symptoms. Avaliable data on alternative short-acting local anaesthetics with respect to transient neurological symptoms are limited and conflicting. Experimental data provide further information on factors contributing to local anaesthetic induced neurotoxicity: adrenaline significantly increases the neurotoxic effects of lignocaine in vivo, whereas the addition of glucose does not.[1]References
- Toxicity of spinal local anaesthetics. Hampl, K.F., Schneider, M.C., Drasner, K. Current opinion in anaesthesiology. (1999) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
