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MeSH Review

Epidemiologic Studies

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Disease relevance of Epidemiologic Studies


Psychiatry related information on Epidemiologic Studies


High impact information on Epidemiologic Studies


Chemical compound and disease context of Epidemiologic Studies


Biological context of Epidemiologic Studies


Anatomical context of Epidemiologic Studies


Associations of Epidemiologic Studies with chemical compounds


Gene context of Epidemiologic Studies

  • Our large population-based genetic epidemiological study has identified a new single-nucleotide substitution (G352A) in the beta(1) gene (KCNMB1), corresponding to an E65K mutation in the protein [36].
  • If HAAs are shown to be human carcinogens in epidemiological studies, then meat cooked at high temperatures may pose an increased cancer risk because it contains both inducers of CYP1A2 and procarcinogens MeIQx, DiMeIQx, and PhIP known to be activated by this enzyme [37].
  • Human epidemiological studies support the involvement of CD14 and TLR4 in cardiovascular diseases [38].
  • Epidemiologic studies have shown an increased frequency of this tumor type in families affected by adenomatous polyposis coli [39].
  • We carried out molecular epidemiological studies of the SH gene during the 1998-1999 seasonal epidemic in New Haven, Connecticut. Strains circulating during the epidemic were related to viruses identified worldwide [40].

Analytical, diagnostic and therapeutic context of Epidemiologic Studies


  1. Caffeine intake and the risk of first-trimester spontaneous abortion. Cnattingius, S., Signorello, L.B., Annerén, G., Clausson, B., Ekbom, A., Ljunger, E., Blot, W.J., McLaughlin, J.K., Petersson, G., Rane, A., Granath, F. N. Engl. J. Med. (2000) [Pubmed]
  2. A single cholesterol measurement underestimates the risk of coronary heart disease. An empirical example from the Lipid Research Clinics Mortality Follow-up Study. Davis, C.E., Rifkind, B.M., Brenner, H., Gordon, D.J. JAMA (1990) [Pubmed]
  3. The relationship between cyclooxygenase-2 expression and colorectal cancer. Sheehan, K.M., Sheahan, K., O'Donoghue, D.P., MacSweeney, F., Conroy, R.M., Fitzgerald, D.J., Murray, F.E. JAMA (1999) [Pubmed]
  4. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. Lamarche, B., Tchernof, A., Mauriège, P., Cantin, B., Dagenais, G.R., Lupien, P.J., Després, J.P. JAMA (1998) [Pubmed]
  5. Increased prevalence of seizure disorders among prisoners. King, L.N., Young, Q.D. JAMA (1978) [Pubmed]
  6. Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study. Ickovics, J.R., Hamburger, M.E., Vlahov, D., Schoenbaum, E.E., Schuman, P., Boland, R.J., Moore, J. JAMA (2001) [Pubmed]
  7. Intake of volatile nitrosamines from consumption of alcohols. Walker, E.A., Castegnaro, M., Garren, L., Toussaint, G., Kowalski, B. J. Natl. Cancer Inst. (1979) [Pubmed]
  8. Nicotine withdrawal symptoms and psychiatric disorders: findings from an epidemiologic study of young adults. Breslau, N., Kilbey, M.M., Andreski, P. The American journal of psychiatry. (1992) [Pubmed]
  9. Risk predictors, risk indicators, and benefit factors in hypertension. Dollery, C.T. Am. J. Med. (1987) [Pubmed]
  10. Saliva cortisol in posttraumatic stress disorder: a community epidemiologic study. Young, E.A., Breslau, N. Biol. Psychiatry (2004) [Pubmed]
  11. Pravastatin therapy and the risk of stroke. White, H.D., Simes, R.J., Anderson, N.E., Hankey, G.J., Watson, J.D., Hunt, D., Colquhoun, D.M., Glasziou, P., MacMahon, S., Kirby, A.C., West, M.J., Tonkin, A.M. N. Engl. J. Med. (2000) [Pubmed]
  12. Heterozygous ATM mutations do not contribute to early onset of breast cancer. FitzGerald, M.G., Bean, J.M., Hegde, S.R., Unsal, H., MacDonald, D.J., Harkin, D.P., Finkelstein, D.M., Isselbacher, K.J., Haber, D.A. Nat. Genet. (1997) [Pubmed]
  13. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The Atherosclerosis Risk in Communities Study Investigators. Nabulsi, A.A., Folsom, A.R., White, A., Patsch, W., Heiss, G., Wu, K.K., Szklo, M. N. Engl. J. Med. (1993) [Pubmed]
  14. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fingerhut, M.A., Halperin, W.E., Marlow, D.A., Piacitelli, L.A., Honchar, P.A., Sweeney, M.H., Greife, A.L., Dill, P.A., Steenland, K., Suruda, A.J. N. Engl. J. Med. (1991) [Pubmed]
  15. The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet. Grimm, R.H., Neaton, J.D., Elmer, P.J., Svendsen, K.H., Levin, J., Segal, M., Holland, L., Witte, L.J., Clearman, D.R., Kofron, P. N. Engl. J. Med. (1990) [Pubmed]
  16. Serum alpha-tocopherol concentration in relation to subsequent colorectal cancer: pooled data from five cohorts. Longnecker, M.P., Martin-Moreno, J.M., Knekt, P., Nomura, A.M., Schober, S.E., Stähelin, H.B., Wald, N.J., Gey, K.F., Willett, W.C. J. Natl. Cancer Inst. (1992) [Pubmed]
  17. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. Wang, X.D., Liu, C., Bronson, R.T., Smith, D.E., Krinsky, N.I., Russell, M. J. Natl. Cancer Inst. (1999) [Pubmed]
  18. Serum hormones and the alcohol-breast cancer association in postmenopausal women. Dorgan, J.F., Baer, D.J., Albert, P.S., Judd, J.T., Brown, E.D., Corle, D.K., Campbell, W.S., Hartman, T.J., Tejpar, A.A., Clevidence, B.A., Giffen, C.A., Chandler, D.W., Stanczyk, F.Z., Taylor, P.R. J. Natl. Cancer Inst. (2001) [Pubmed]
  19. Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Seitz, H.K., Simanowski, U.A., Garzon, F.T., Rideout, J.M., Peters, T.J., Koch, A., Berger, M.R., Einecke, H., Maiwald, M. Gastroenterology (1990) [Pubmed]
  20. Oral contraceptives and breast cancer. Progress report of an epidemiological study. Vessey, M.P., Doll, R., Jones, K. Lancet (1975) [Pubmed]
  21. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. Hankinson, S.E., Willett, W.C., Manson, J.E., Hunter, D.J., Colditz, G.A., Stampfer, M.J., Longcope, C., Speizer, F.E. J. Natl. Cancer Inst. (1995) [Pubmed]
  22. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Tremolizzo, L., Carboni, G., Ruzicka, W.B., Mitchell, C.P., Sugaya, I., Tueting, P., Sharma, R., Grayson, D.R., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  23. Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone. Kisselev, P., Schunck, W.H., Roots, I., Schwarz, D. Cancer Res. (2005) [Pubmed]
  24. The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Jaziri, R., Lobbens, S., Aubert, R., Péan, F., Lahmidi, S., Vaxillaire, M., Porchay, I., Bellili, N., Tichet, J., Balkau, B., Froguel, P., Marre, M., Fumeron, F. Diabetes (2006) [Pubmed]
  25. Is there a vitamin E paradox? Jialal, I., Traber, M., Devaraj, S. Curr. Opin. Lipidol. (2001) [Pubmed]
  26. HDL and triglyceride as therapeutic targets. Fruchart, J.C., Duriez, P. Curr. Opin. Lipidol. (2002) [Pubmed]
  27. Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases. Stewart, T.A. Cytokine Growth Factor Rev. (2003) [Pubmed]
  28. Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation. Monticello, T.M., Morgan, K.T., Everitt, J.I., Popp, J.A. Am. J. Pathol. (1989) [Pubmed]
  29. Piroxicam in recent epidemiologic studies. Bortnichak, E.A., Sachs, R.M. Am. J. Med. (1986) [Pubmed]
  30. Subcutaneous adipose-tissue fatty acids and vitamin E in humans: relation to diet and sampling site. Schäfer, L., Overvad, K. Am. J. Clin. Nutr. (1990) [Pubmed]
  31. Relation of serum vitamins A and E and carotenoids to the risk of cancer. Willett, W.C., Polk, B.F., Underwood, B.A., Stampfer, M.J., Pressel, S., Rosner, B., Taylor, J.O., Schneider, K., Hames, C.G. N. Engl. J. Med. (1984) [Pubmed]
  32. Low-risk cigarettes: a prescription. Gori, G.B. Science (1976) [Pubmed]
  33. Self-reported exposure to neurotoxic chemical combinations in the Gulf War. A cross-sectional epidemiologic study. Haley, R.W., Kurt, T.L. JAMA (1997) [Pubmed]
  34. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. Fang, J., Alderman, M.H. JAMA (2000) [Pubmed]
  35. Prescribing of tetracycline to children less than 8 years old. A two-year epidemiologic study among ambulatory Tennessee medicaid recipients. Ray, W.A., Federspiel, C.F., Schaffner, W. JAMA (1977) [Pubmed]
  36. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. Fernández-Fernández, J.M., Tomás, M., Vázquez, E., Orio, P., Latorre, R., Sentí, M., Marrugat, J., Valverde, M.A. J. Clin. Invest. (2004) [Pubmed]
  37. Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Sinha, R., Rothman, N., Brown, E.D., Mark, S.D., Hoover, R.N., Caporaso, N.E., Levander, O.A., Knize, M.G., Lang, N.P., Kadlubar, F.F. Cancer Res. (1994) [Pubmed]
  38. Oxidized low density lipoprotein and innate immune receptors. Miller, Y.I., Chang, M.K., Binder, C.J., Shaw, P.X., Witztum, J.L. Curr. Opin. Lipidol. (2003) [Pubmed]
  39. Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma. Bläker, H., Hofmann, W.J., Rieker, R.J., Penzel, R., Graf, M., Otto, H.F. Genes Chromosomes Cancer (1999) [Pubmed]
  40. Conservation of the respiratory syncytial virus SH gene. Chen, M.D., Vazquez, M., Buonocore, L., Kahn, J.S. J. Infect. Dis. (2000) [Pubmed]
  41. Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. Neuberger, J., Allen, A. J. Natl. Cancer Inst. (1997) [Pubmed]
  42. Molecular genetics of amyloid neuropathy in Europe. Holt, I.J., Harding, A.E., Middleton, L., Chrysostomou, G., Said, G., King, R.H., Thomas, P.K. Lancet (1989) [Pubmed]
  43. Are certain diuretics also anticonvulsants? Hesdorffer, D.C., Stables, J.P., Hauser, W.A., Annegers, J.F., Cascino, G. Ann. Neurol. (2001) [Pubmed]
  44. Overview of clinical trials of cholesterol lowering in relationship to epidemiologic studies. Tyroler, H.A. Am. J. Med. (1989) [Pubmed]
  45. Antioxidant vitamins and coronary artery disease risk. Gaziano, J.M. Am. J. Med. (1994) [Pubmed]
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