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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prohibitin binds to C3 and enhances complement activation.

Prohibitin (PHB1) is a multifunction protein that is released in lipid droplets from adipocytes and possibly other cells and is detectable in the circulation. We used crosslinking, immunoprecipitation and proteomic analysis to investigate binding partners for circulating PHB1. Crosslinking of PHB1 to serum resulted in two complexes of approximately 150 and 100kDa, which contained both PHB1 and fragments of C3. The binding of PHB1 to C3 was confirmed using a solid phase assay where the dissociation constant was approximately 90fmol/l. PHB1, but not the closely related PHB2, was able to enhance complement activation and induce lysis of sensitized sheep erythrocytes when added with normal serum but not with C3-deficient serum. The ability of PHB1 to bind to, and activate C3 suggests that PHB1 may have a previously unrecognized role in innate immunity.[1]


  1. Prohibitin binds to C3 and enhances complement activation. Mishra, S., Moulik, S., Murphy, L.J. Mol. Immunol. (2007) [Pubmed]
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