Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice.
The effects of peptidase inhibitors were examined upon behavioural responses including scratch, bite and lick produced by intrathecal (IT) injection of substance P (SP) and neurokinin A ( NK A) in mice. Phosphoramidon (0.002-2.0 nmol), an endopeptidase-24.11 inhibitor, simultaneously injected with SP or NK A, remarkably enhanced and prolonged SP- or NK A-induced behavioural response in a dose-dependent manner. The behavioural response to SP was significantly increased by 2.0 nmol of bestatin, an aminopeptidase inhibitor, but not by 1.0 nmol. Captopril, an angiotensin-converting enzyme inhibitor, was without effect on both tachykinin-induced responses. When phosphoramidon was injected together with bestatin and captopril which have no significant effect alone, SP- or NK A-induced behavioral response was significantly increased. These data suggest that endopeptidase-24.11 may be an important enzyme responsible for terminating of SP- or NK A-induced behavioral response at the spinal cord level.[1]References
- Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice. Sakurada, T., Tan-No, K., Yamada, T., Sakurada, S., Kisara, K. Pharmacol. Biochem. Behav. (1990) [Pubmed]
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