Two alpha-herpesvirus strains are transported differentially in the rodent visual system.
Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However, the location of infected forebrain neurons varied with the strain of virus. Intravitreal injection of wild-type virus produced two temporally separated waves of infection that eventually reached all known retino-recipient regions of the central neuraxis. By contrast, the attenuated strain of PRV selectively infected a functionally distinct subset of retinal ganglion cells with restricted central projections. The data indicate that projection-specific groups of ganglion cells are differentially susceptible to the two strains of virus and suggest that this sensitivity may be receptor mediated.[1]References
- Two alpha-herpesvirus strains are transported differentially in the rodent visual system. Card, J.P., Whealy, M.E., Robbins, A.K., Moore, R.Y., Enquist, L.W. Neuron (1991) [Pubmed]
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