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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of arsanilic Acid on performance and residual of arsenic in tissue of Japanese laying quail.

Three hundred seventy-five 63-d-old laying Japanese quail were randomly distributed into 3 experimental groups (125 birds per group) and fed the following diets for 40 d, with 30 d on the experimental diets, followed by a 10-d withdrawal period: 1) control; 2) 50 mg of 4-arsanilic acid/kg of feed; and 3) 100 mg of 4-arsanlic acid/kg of feed. Each treatment consisted of 5 replicates of 25 birds. During the first 30 d of the experiment, all eggs were recorded, collected, individually weighed daily, and feed consumption was determined every 10 d. Five quail from each replicate in the experiment were euthanized by cervical dislocation at 0, 30, 35, and 40 d. Tissue samples from the liver, kidney, heart, gizzard, and the muscle on the breast and leg were collected for determination of As residue. The feces and eggs at 0, 30, 35, and 40 d of the experiment were selected for determination of As. Results showed that dietary inclusion of 50 and 100 mg/kg of 4-arsanilic acid significantly improved feed utilization and egg production, but the concentration of As in the tissues and feces in groups fed 4-arsanilic acid was higher than in control group. The results of the present study demonstrate that the use of organic As compounds as feed additives in diet is a matter for argument.[1]


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