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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antibodies to retroviral proteins and reverse transcriptase activity in patients with essential cryoglobulinemia.

Human T cell lymphotropic virus type I (HTLV-I) gag and env protein-specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV-I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV-I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV-I may be involved in the pathogenesis of EC in some patients.[1]

References

  1. Antibodies to retroviral proteins and reverse transcriptase activity in patients with essential cryoglobulinemia. Perl, A., Gorevic, P.D., Condemi, J.J., Papsidero, L., Poiesz, B.J., Abraham, G.N. Arthritis Rheum. (1991) [Pubmed]
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