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Disease relevance of Cryoglobulinemia


High impact information on Cryoglobulinemia

  • Although much has been learned about the molecular basis of immunoglobulin M (IgM) rheumatoid factors (RFs) in healthy individuals and in patients with mixed cryoglobulinemia and rheumatoid arthritis, little is known about the genetic origins of the potentially pathogenic IgG RFs in the inflamed rheumatoid synovia of patients [6].
  • None were detected in patients with systemic lupus erythematosus and idiopathic cryoglobulinemia [7].
  • Polymerase chain reaction detected HCV RNA in 13 of 16 sera from patients with essential mixed cryoglobulinemia [8].
  • Similar skin vascular and glomerular lesions associated with cryoglobulinemia can be induced in normal mice by injection of a monoclonal antibody (mAb)--6-19 (gamma 3 heavy chain and kappa light chain), exhibiting both cryoglobulin and anti-IgG2a rheumatoid factor (RF) activities--derived from the MRL-lpr/lpr autoimmune mouse [9].
  • We evaluated the effects of interferon and ribavirin on serum, B-lymphocyte HCV RNA, and t(14; 18) in 30 HCV+, t(14;18)+ patients without either mixed cryoglobulinemia syndrome or other LPDs [10].

Chemical compound and disease context of Cryoglobulinemia


Biological context of Cryoglobulinemia


Anatomical context of Cryoglobulinemia


Gene context of Cryoglobulinemia


Analytical, diagnostic and therapeutic context of Cryoglobulinemia


  1. Hepatitis B antigen associated with cryoglobulinemia, peripheral neuropathy, and myopathy. Flatau, E., Resnitzky, P., Kohn, D. JAMA (1980) [Pubmed]
  2. Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: relationship to antibody response against hypervariable region genome. Aiyama, T., Yoshioka, K., Okumura, A., Takayanagi, M., Iwata, K., Ishikawa, T., Kakumu, S. Hepatology (1996) [Pubmed]
  3. Extrahepatic manifestations of hepatitis C among United States male veterans. El-Serag, H.B., Hampel, H., Yeh, C., Rabeneck, L. Hepatology (2002) [Pubmed]
  4. Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia. Wener, M.H., Hutchinson, K., Morishima, C., Gretch, D.R. Arthritis Rheum. (2004) [Pubmed]
  5. Hypertrophic osteoarthropathy, cutaneous vasculitis, and mixed-type cryoglobulinemia in a patient with nasopharyngeal carcinoma. Miyachi, H., Akizuki, M., Yamagata, H., Mimori, T., Yoshida, S., Homma, M. Arthritis Rheum. (1987) [Pubmed]
  6. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. Olee, T., Lu, E.W., Huang, D.F., Soto-Gil, R.W., Deftos, M., Kozin, F., Carson, D.A., Chen, P.P. J. Exp. Med. (1992) [Pubmed]
  7. Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype. Agnello, V., Arbetter, A., Ibanez de Kasep, G., Powell, R., Tan, E.M., Joslin, F. J. Exp. Med. (1980) [Pubmed]
  8. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. Misiani, R., Bellavita, P., Fenili, D., Borelli, G., Marchesi, D., Massazza, M., Vendramin, G., Comotti, B., Tanzi, E., Scudeller, G. Ann. Intern. Med. (1992) [Pubmed]
  9. Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms. Reininger, L., Berney, T., Shibata, T., Spertini, F., Merino, R., Izui, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation. Giannelli, F., Moscarella, S., Giannini, C., Caini, P., Monti, M., Gragnani, L., Romanelli, R.G., Solazzo, V., Laffi, G., La Villa, G., Gentilini, P., Zignego, A.L. Blood (2003) [Pubmed]
  11. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. Trendelenburg, M., Fossati-Jimack, L., Cortes-Hernandez, J., Turnberg, D., Lewis, M., Izui, S., Cook, H.T., Botto, M. J. Immunol. (2005) [Pubmed]
  12. Reversal of systemic manifestations of cryoglobulinemia. Treatment with melphalan and prednisone. Ristow, S.C., Griner, P.F., Abraham, G.N., Shoulson, I. Arch. Intern. Med. (1976) [Pubmed]
  13. Acute cryoglobulinemic renal failure after intravenous infusion of gamma globulin. Barton, J.C., Herrera, G.A., Galla, J.H., Bertoli, L.F., Work, J., Koopman, W.J. Am. J. Med. (1987) [Pubmed]
  14. Behçet's syndrome. Report of a case associated with pericardial effusion and cryoglobulinemia treated with indomethacin. Scarlett, J.A., Kistner, M.L., Yang, L.C. Am. J. Med. (1979) [Pubmed]
  15. Multiple myeloma, cryoglobulinemia and xanthomatosis. Distinct clinical and biochemical syndromes in two patients. Wilson, D.E., Floweres, C.M., Hershgold, E.J., Eaton, R.P. Am. J. Med. (1975) [Pubmed]
  16. Th1/Th2 cytokine imbalance in patients with Sjögren syndrome secondary to hepatitis C virus infection. Ramos-Casals, M., García-Carrasco, M., Cervera, R., Filella, X., Trejo, O., de la Red, G., Gil, V., Sánchez-Tapias, J.M., Font, J., Ingelmo, M. Semin. Arthritis Rheum. (2002) [Pubmed]
  17. Hepatitis C virus genotypes implicated in mixed cryoglobulinemia. Nguyen, Q.T., Leruez-Ville, M., Ferrière, F., Cohen, P., Roulot-Marullo, D., Coste, T., Dény, P., Guillevin, L. J. Med. Virol. (1998) [Pubmed]
  18. Low number of complement C3b/C4b receptors (CR1) on erythrocytes from patients with essential mixed cryoglobulinemia, systemic lupus erythematosus and rheumatoid arthritis: relationship with disease activity, anticardiolipin antibodies, complement activation and therapy. Corvetta, A., Pomponio, G., Bencivenga, R., Luchetti, M.M., Spycher, M., Spaeth, P.J., Danieli, G. J. Rheumatol. (1991) [Pubmed]
  19. Effect of alpha-interferon on hepatitis C virus chronic infection in mixed cryoglobulinemia patients. Ferri, C., Zignego, A.L., Longombardo, G., Monti, M., La Civita, L., Lombardini, F., Greco, F., Mazzoni, A., Pasero, G., Gentilini, P. Infection (1993) [Pubmed]
  20. Prevalence of cryoglobulins and hepatitis C virus infection in HIV-infected patients. Cohen, P., Roulot, D., Ferrière, F., Nguyen, Q.T., Lortholary, O., Jarrousse, B., Dény, P., Coste, T., Robineau, M., Guillevin, L. Clinical and experimental rheumatology. (1997) [Pubmed]
  21. Importance of the IgG isotype, not the state of glycosylation, in determining human rheumatoid factor binding. Newkirk, M.M., Lemmo, A., Rauch, J. Arthritis Rheum. (1990) [Pubmed]
  22. Unusual IgM fibrillar deposits in glomerulonephritis: ultrastructural and diffraction studies in a case report. Nabarra, B., Larquet, E., Diemert, M.C., Leblond, V., Baumelou, A., Beaufils, H. Hum. Pathol. (2003) [Pubmed]
  23. Pseudothrombocytosis and pseudoleukocytosis in a case of essential mixed cryoglobulinemia (type II). Di Giovanni, S., De Matteis, M.A., Ciocca, D., Cirella, M.P., Nanni Costa, M.P. Clinical and experimental rheumatology. (1986) [Pubmed]
  24. Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C. Rostaing, L., Oksman, F., Izopet, J., Baron, E., Cisterne, J.M., Hoff, M., Abbal, M., Durand, D. American journal of nephrology. (1996) [Pubmed]
  25. Clinical serological correlations in the evaluation of Sjögren's syndrome. Valesini, G., Priori, R., Borsetti, A., Tiberti, A., Moncada, A., Pivetti-Pezzi, P. Clinical and experimental rheumatology. (1989) [Pubmed]
  26. Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice. Taneda, S., Segerer, S., Hudkins, K.L., Cui, Y., Wen, M., Segerer, M., Wener, M.H., Khairallah, C.G., Farr, A.G., Alpers, C.E. Am. J. Pathol. (2001) [Pubmed]
  27. Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in the pathogenesis of severe forms of vasculitis due to hepatitis C-associated mixed cryoglobulinemia. Kaplanski, G., Maisonobe, T., Marin, V., Grès, S., Robitail, S., Farnarier, C., Harlé, J.R., Piette, J.C., Cacoub, P. J. Hepatol. (2005) [Pubmed]
  28. Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with Sjögren's syndrome and type II mixed cryoglobulinemia. Bertolo, F., De Vita, S., Dolcetti, R., Carbone, A., Ferraccioli, G.F., Bartoli, E., Boiocchi, M. Clinical and experimental rheumatology. (1999) [Pubmed]
  29. Murine cryoglobulinemia: pathogenic and protective IgG3 self-associating antibodies. Berney, T., Shibata, T., Izui, S. J. Immunol. (1991) [Pubmed]
  30. Nonrheumatoid IgM in human hepatitis C virus-associated type II cryoglobulinemia recognize mimotopes of the CD4-like LAG-3 protein. Mecchia, M., Casato, M., Tafi, R., Filocamo, G., Bonomo, L., Fiorilli, M., Cortese, R., Migliaccio, G., Nicosia, A. J. Immunol. (1996) [Pubmed]
  31. Hepatitis C virus but not GB virus C/hepatitis G virus has a role in type II cryoglobulinemia. Liu, F., Knight, G.B., Agnello, V. Arthritis Rheum. (1999) [Pubmed]
  32. Immune complex behaviour during prolonged plasma exchange in essential mixed cryoglobulinemia and systemic lupus erythematosus. Bombardieri, S., Ferri, C., Migliorini, P., Puccetti, A., Vitali, C., Moriconi, L., Fosella, P.V. The International journal of artificial organs. (1985) [Pubmed]
  33. A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. Ballarè, M., Bobbio, F., Poggi, S., Bordin, G., Bertoncelli, M.C., Catania, E., Monteverde, A. Clinical and experimental rheumatology. (1995) [Pubmed]
  34. Macroglobulinemia and membranoproliferative glomerulonephritis in a hepatitis C virus-positive patient. Akashi, Y., Inoh, M., Gamou, N., Yoshimune, N., Kinashi, M., Ohbayashi, S., Kurata, N. Clin. Nephrol. (2003) [Pubmed]
  35. Clinical significance of cross-linked fibrin degradation products in essential mixed cryoglobulinemia. Fiorini, G., Toschi, V., Motta, A., Gagliano, M.G., Gibelli, A. Biomed. Pharmacother. (1988) [Pubmed]
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