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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetically selected stem cells from human adipose tissue express cardiac markers.

In the present study, the potential of human adipose-derived stem cells to differentiate into cells with characteristics of cardiomyocytes was investigated. Adipose tissue-derived stem cells (ADSCs) were transduced with two different lentiviral vectors simultaneously: (1) a lentiviral vector expressing eGFP controlled by the Nkx2.5 promoter and (2) a lentiviral vector expressing DsRed2 controlled by the myosin light chain-2v promoter (MLC-2v). Nkx2.5-eGFP and MLC-2v-DsRed2 dual positive cells were isolated by FACS. Immunostaining and RT-PCR analysis of the dual positive cells revealed that these cells are positive for Nkx2.5, cardiac troponin I, and L-type calcium channel alpha-1c subunit. Electrophysiology studies demonstrated the presence of functional voltage-dependent calcium and potassium channels. These observations confirm that cardiac progenitor cells can be isolated and enriched from human adipose-derived stem cells using lentiviral selection, and they might represent a new source for cell therapy for myocardial infarction and heart failure.[1]


  1. Genetically selected stem cells from human adipose tissue express cardiac markers. Bai, X., Pinkernell, K., Song, Y.H., Nabzdyk, C., Reiser, J., Alt, E. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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