Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Jabs, D.A. et al.

Douglas A. Jabs, Mark L. Van Natta, Janet T. Holbrook, John H. Kempen, Curtis L. Meinert, Matthew D. Davis,

Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment.

OBJECTIVE: To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART). DESIGN: Cohort study. PARTICIPANTS: Patients with AIDS, 13 years or older. METHODS: History, eye examination, and laboratory testing at enrollment. MAIN OUTCOME MEASURE: Frequency of ocular complications at enrollment. RESULTS: As of March 31, 2003, 1632 participants with AIDS were enrolled. The cohort had a history of severe immune deficiency, as evidenced by a median nadir CD4+ T-cell count of 30 cells per microliter. At enrollment, the median CD4+ T-cell count was 164 cells per microliter. CD4+ T-cell counts were <50 in 24.1% but > or =100 in 63.6% and > or =200 in 43.0%. Cytomegalovirus (CMV) retinitis was present in 22.1%, whereas other ocular opportunistic infections each were present in < or =0.6%. The incidence of CMV retinitis estimated from retrospective data was 5.60/100 person-years. Of the 360 patients with CMV retinitis, 22.5% were newly diagnosed at enrollment, and the remainder had more long-standing CMV retinitis (median, 2.8 years). CONCLUSIONS: Although there is the possibility of oversampling patients with AIDS and ocular complications (as compared with a random sample), which would lead to increased estimates of prevalent and incident ocular morbidities, these data still suggest a substantial decline in the incidence of CMV retinitis from the pre-HAART era. Nevertheless, new cases of CMV retinitis continue to occur, and there is a population of patients with long-standing retinitis who will require management.[1]

References

Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Jabs, D.A., Van Natta, M.L., Holbrook, J.T., Kempen, J.H., Meinert, C.L., Davis, M.D. Ophthalmology (2007) [Pubmed]

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