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Hale, B.G. et al.

PI3K signalling during influenza A virus infections.

Recent work has demonstrated that the PI3K (phosphoinositide 3-kinase) signalling pathway is important for efficient influenza A virus replication. Activation of PI3K in virus-infected cells is mediated by the viral NS1 protein, which binds directly to the p85beta regulatory subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs.[1]

References

PI3K signalling during influenza A virus infections. Hale, B.G., Randall, R.E. Biochem. Soc. Trans. (2007) [Pubmed]

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