Gene Review:
PTPN11 - protein tyrosine phosphatase, non-receptor...
Homo sapiens
Synonyms:
BPTP3, CFC, NS1, PTP-1D, PTP-2C, ...
Monteleone,
Pession,
Brubaker,
Siguero,
Asada,
Bellinvia,
Jeffery,
Mizutani,
Carta,
Calabrese,
Cordeddu,
Munugalavadla,
Yu,
Dallapiccola,
Gelb,
Vogel,
Bristow,
Osawa,
Monteleone,
Spinelli,
Mira,
Pandit,
Curry,
Fina,
Lepri,
Tartaglia,
Naccari,
Mehler,
Zhao,
Kapur,
Martin,
Koizumi,
Gelb,
Pallone,
Gómez-Mouton,
Kucherlapati,
Li,
Sarkozy,
Dong,
Biondi,
Zhang,
Harada,
Ikeuchi,
Liang,
Palmi,
Neri,
Gibson,
Yamada,
Dong,
Voorhorst,
Vavassori,
Matozaki,
Basso,
Fang,
Masuda,
Ullrich,
Martínez-A,
Lanier,
He,
Oishi,
Cazzaniga,
Fujiwara,
Carta,
Martinelli,
Ustaszewska,
Feng,
Kalidas,
Shigematsu,
Pennacchio,
Iavarone,
Bar-Sagi,
Wittekindt,
Yadav,
Vasta,
Lu,
Martinelli,
Chernock,
Zhao,
Xu,
van der Burgt,
Gelb,
Gan,
Zheng,
Suzuki,
Lacalle,
Crosby,
Mañes,
Braun,
Groopman,
Tartaglia,
Chan,
Avraham,
Deichmann,
Yu,
Testi,
Caruso,
Digilio,
Kruse,
Kremer,
Schackwitz,
Leedy,
Ranke,
Patton,
Aricò,
Fodale,
Zhang,
Zampino,
Neuer,
Ion,
Zampino,
Zhao,
Sorcini,
Xu,
Tartaglia,
Hatanaka,
Masera,
Franchi,
Ganju,
Goldberg,
Brunner,
Binder,
- Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Tartaglia, M., Mehler, E.L., Goldberg, R., Zampino, G., Brunner, H.G., Kremer, H., van der Burgt, I., Crosby, A.H., Ion, A., Jeffery, S., Kalidas, K., Patton, M.A., Kucherlapati, R.S., Gelb, B.D. Nat. Genet. (2001)
- Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Tartaglia, M., Niemeyer, C.M., Fragale, A., Song, X., Buechner, J., Jung, A., Hählen, K., Hasle, H., Licht, J.D., Gelb, B.D. Nat. Genet. (2003)
- Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Digilio, M.C., Conti, E., Sarkozy, A., Mingarelli, R., Dottorini, T., Marino, B., Pizzuti, A., Dallapiccola, B. Am. J. Hum. Genet. (2002)
- PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Tartaglia, M., Kalidas, K., Shaw, A., Song, X., Musat, D.L., van der Burgt, I., Brunner, H.G., Bertola, D.R., Crosby, A., Ion, A., Kucherlapati, R.S., Jeffery, S., Patton, M.A., Gelb, B.D. Am. J. Hum. Genet. (2002)
- Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Tartaglia, M., Martinelli, S., Cazzaniga, G., Cordeddu, V., Iavarone, I., Spinelli, M., Palmi, C., Carta, C., Pession, A., Aricò, M., Masera, G., Basso, G., Sorcini, M., Gelb, B.D., Biondi, A. Blood (2004)
- Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. Zhang, W., Chan, R.J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L.C., Payne, R.M., Zhang, Z.Y., Fu, X.Y., Shou, W. J. Biol. Chem. (2009)
- Temporal framing and the decision to take part in type 2 diabetes screening: effects of individual differences in consideration of future consequences on persuasion. Orbell, S., Hagger, M. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. (2006)
- Integrating social value orientation and the consideration of future consequences within the extended norm activation model of proenvironmental behaviour. Joireman, J.A., Lasane, T.P., Bennett, J., Richards, D., Solaimani, S. The British journal of social psychology / the British Psychological Society. (2001)
- NK cell receptors. Lanier, L.L. Annu. Rev. Immunol. (1998)
- Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Tartaglia, M., Pennacchio, L.A., Zhao, C., Yadav, K.K., Fodale, V., Sarkozy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., Ustaszewska, A., Martin, J., Bristow, J., Carta, C., Lepri, F., Neri, C., Vasta, I., Gibson, K., Curry, C.J., Siguero, J.P., Digilio, M.C., Zampino, G., Dallapiccola, B., Bar-Sagi, D., Gelb, B.D. Nat. Genet. (2007)
- Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Niihori, T., Aoki, Y., Narumi, Y., Neri, G., Cavé, H., Verloes, A., Okamoto, N., Hennekam, R.C., Gillessen-Kaesbach, G., Wieczorek, D., Kavamura, M.I., Kurosawa, K., Ohashi, H., Wilson, L., Heron, D., Bonneau, D., Corona, G., Kaname, T., Naritomi, K., Baumann, C., Matsumoto, N., Kato, K., Kure, S., Matsubara, Y. Nat. Genet. (2006)
- Germline KRAS mutations cause Noonan syndrome. Schubbert, S., Zenker, M., Rowe, S.L., Böll, S., Klein, C., Bollag, G., van der Burgt, I., Musante, L., Kalscheuer, V., Wehner, L.E., Nguyen, H., West, B., Zhang, K.Y., Sistermans, E., Rauch, A., Niemeyer, C.M., Shannon, K., Kratz, C.P. Nat. Genet. (2006)
- Vanadate regulates the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma cells. Bifulco, G., Caruso, M., Di Carlo, C., Acunzo, G., Votino, C., Pellicano, M., Beguinot, F., Nappi, C. Gynecol. Endocrinol. (2003)
- Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. Han, X., Sosnowska, D., Bonkowski, E.L., Denson, L.A. Gastroenterology (2005)
- Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells. Monteleone, G., Franchi, L., Fina, D., Caruso, R., Vavassori, P., Monteleone, I., Calabrese, E., Naccari, G.C., Bellinvia, S., Testi, R., Pallone, F. Cell Death Differ. (2006)
- In vivo protection of normal mouse hematopoiesis by a beta 2 blocking agent during S-phase chemotherapy. Dresch, C., Minc, J., Mary, J.Y. Cancer Res. (1984)
- Expression of HCV E2/NS1 protein as a fusion protein with maltose binding protein: detection of anti-E2/NS1 antibody in chronic liver disease. Yokosuka, O., Omata, M., Ito, Y., Ohto, M. Gut (1993)
- NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome. De Luca, A., Bottillo, I., Sarkozy, A., Carta, C., Neri, C., Bellacchio, E., Schirinzi, A., Conti, E., Zampino, G., Battaglia, A., Majore, S., Rinaldi, M.M., Carella, M., Marino, B., Pizzuti, A., Digilio, M.C., Tartaglia, M., Dallapiccola, B. Am. J. Hum. Genet. (2005)
- The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. Kratz, C.P., Niemeyer, C.M., Castleberry, R.P., Cetin, M., Bergsträsser, E., Emanuel, P.D., Hasle, H., Kardos, G., Klein, C., Kojima, S., Stary, J., Trebo, M., Zecca, M., Gelb, B.D., Tartaglia, M., Loh, M.L. Blood (2005)
- Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Xu, R., Yu, Y., Zheng, S., Zhao, X., Dong, Q., He, Z., Liang, Y., Lu, Q., Fang, Y., Gan, X., Xu, X., Zhang, S., Dong, Q., Zhang, X., Feng, G.S. Blood (2005)
- Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. Pazdrak, K., Adachi, T., Alam, R. J. Exp. Med. (1997)
- Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Chan, R.J., Leedy, M.B., Munugalavadla, V., Voorhorst, C.S., Li, Y., Yu, M., Kapur, R. Blood (2005)
- Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mañes, S., Mira, E., Gómez-Mouton, C., Zhao, Z.J., Lacalle, R.A., Martínez-A, C. Mol. Cell. Biol. (1999)
- Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. Stofega, M.R., Argetsinger, L.S., Wang, H., Ullrich, A., Carter-Su, C. J. Biol. Chem. (2000)
- Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells. Ling, Y., Maile, L.A., Lieskovska, J., Badley-Clarke, J., Clemmons, D.R. Mol. Biol. Cell (2005)
- Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Chen, L., Sung, S.S., Yip, M.L., Lawrence, H.R., Ren, Y., Guida, W.C., Sebti, S.M., Lawrence, N.J., Wu, J. Mol. Pharmacol. (2006)
- The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta. Strack, V., Krützfeldt, J., Kellerer, M., Ullrich, A., Lammers, R., Häring, H.U. Biochemistry (2002)
- The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases. Mitchell, D., O'Meara, S.J., Gaffney, A., Crean, J.K., Kinsella, B.T., Godson, C. J. Biol. Chem. (2007)
- Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. Kapoor, G.S., Zhan, Y., Johnson, G.R., O'Rourke, D.M. Mol. Cell. Biol. (2004)
- Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. Yamada, M., Suzuki, K., Mizutani, M., Asada, A., Matozaki, T., Ikeuchi, T., Koizumi, S., Hatanaka, H. J. Biochem. (2001)
- Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain. Kruse, S., Braun, S., Deichmann, K.A. Respir. Res. (2002)
- Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. Masuda, M., Osawa, M., Shigematsu, H., Harada, N., Fujiwara, K. FEBS Lett. (1997)
- Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. Vogel, W., Ullrich, A. Cell Growth Differ. (1996)
- Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y., Kasuga, M. Mol. Cell. Biol. (1994)
- Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Vogel, W., Lammers, R., Huang, J., Ullrich, A. Science (1993)
- Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. Cunnick, J.M., Mei, L., Doupnik, C.A., Wu, J. J. Biol. Chem. (2001)
- Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Peraldi, P., Zhao, Z., Filloux, C., Fischer, E.H., Van Obberghen, E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. Lundin Brockdorff, J., Woetmann, A., Mustelin, T., Kaltoft, K., Zhang, Q., Wasik, M.A., Röpke, C., Ødum, N. Cytokine (2002)
- Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. Kim, H., Baumann, H. Mol. Cell. Biol. (1999)
- Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. Ganju, R.K., Brubaker, S.A., Chernock, R.D., Avraham, S., Groopman, J.E. J. Biol. Chem. (2000)
- Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2. Wong, L., Johnson, G.R. J. Biol. Chem. (1996)
- SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. Bjorbak, C., Lavery, H.J., Bates, S.H., Olson, R.K., Davis, S.M., Flier, J.S., Myers, M.G. J. Biol. Chem. (2000)
- Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. Jakob, S., Schroeder, P., Lukosz, M., Büchner, N., Spyridopoulos, I., Altschmied, J., Haendeler, J. J. Biol. Chem. (2008)
- PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome. Binder, G., Neuer, K., Ranke, M.B., Wittekindt, N.E. J. Clin. Endocrinol. Metab. (2005)
- Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome. Yoshida, R., Hasegawa, T., Hasegawa, Y., Nagai, T., Kinoshita, E., Tanaka, Y., Kanegane, H., Ohyama, K., Onishi, T., Hanew, K., Okuyama, T., Horikawa, R., Tanaka, T., Ogata, T. J. Clin. Endocrinol. Metab. (2004)
- Exclusion of PTPN11 mutations in Costello syndrome: further evidence for distinct genetic etiologies for Noonan, cardio-facio-cutaneous and Costello syndromes. Tartaglia, M., Cotter, P.D., Zampino, G., Gelb, B.D., Rauen, K.A. Clin. Genet. (2003)
- Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation. Fragale, A., Tartaglia, M., Wu, J., Gelb, B.D. Hum. Mutat. (2004)
- Leptin receptor signaling and the regulation of mammalian physiology. Myers, M.G. Recent Prog. Horm. Res. (2004)