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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Studies on antiatherosclerotic agents. Synthesis of 5-substituted derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)

Several 5-substituted derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)- phthalazinone were prepared by means of nitration, reductive amination, and diazonium decomposition. The substituents introduced included NO2, NH2, F, Cl, CN. Among the derivatives, the fluorine compound was obtained only in poor yield because intramolecular cyclization occurred predominantly.[1]


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