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Chemical Compound Review

cyanyl     azanylidynemethane

Synonyms: Cyano radical, AC1NSDX2, CHEBI:29306, CN(.), (CN)(.), ...
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Disease relevance of nitridomethane

  • In liver microsomes from four patients (A, B, C, and D) with Crigler-Najjar syndrome type I (CN type I), UDPGT activity towards bilirubin was undetectable (A, B, C, and D) and activity towards phenolic compounds and 5-hydroxytryptamine either reduced (A and B) or normal (C and D) [1].
  • BACKGROUND: Inherited unconjugated hyperbilirubinemia in Crigler-Najjar type II (CN II) is caused by a strong reduction of bilirubin uridine 5'-diphosphate-glucuronosyltransferase (B-UGT) activity [2].
  • Inhibitory insulin-like growth factor binding protein (In-IGF-BP) has been purified to homogeneity from medium conditioned by TE89 human osteosarcoma cells by two different methods using Sephadex G-100 gel filtration, FPLC Mono Q ion-exchange, HPLC C4 reverse-phase, HPLC CN reverse-phase, and affinity chromatographies [3].
  • (Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789, 1963), may be responsible for this phenomenon, we studied nine prepubertal (Tanner I), nine pubertal (Tanner II-IV), and five young adult healthy subjects [4].
  • -to: Hales CN, Ozanne SE (2003) for debate: fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013-1019 [5].

Psychiatry related information on nitridomethane

  • In both the RP and the CN groups, the maximum decrease in psychopathology was achieved with the lowest dose range [6].
  • Exposure to ethanol during pregnancy is detrimental to fetal development, and individuals affected by the fetal alcohol syndrome present a number of CN system dysfunctions including microencephaly and mental retardation [7].
  • In the present study CB development is compared between healthy children (CN), children with attention deficit (ADHD) and those with complex tics or Tourette's syndrome (TS) with mean ages of 10-11 years [8].
  • Despite the fact that a peripheral/central distinction is useful in clinical audiology (where threshold loss is commonly associated with CN VIII pathology), an evaluation of the utility of this distinction in olfaction requires further research [9].

High impact information on nitridomethane

  • Their similar x-ray and optical properties indicate that the stars make up a physical association that is on the order of 20 million years old and that lies between about 40 and 60 parsecs (between about 130 and 200 light years) from Earth. TW Hya itself displays circumstellar CO, HCN, CN, and HCO+ emission [10].
  • CN OVA-specific effectors were also CD8+, CD4-, but surprisingly, were able to lyse a range of H-2-different targets in an antigen-specific manner [11].
  • Six out of eight clones from a major specificity group, which failed to recognize variants TX/77, BK/79, or CN/84, responded to two overlapping peptides (48-68 and 53-87), corresponding to a region of HA1 that includes part of two antibody combining sites [12].
  • The human granule NADPH oxidase, as measured by this assay, is active in the presence of CN minus, is stimulated by Mn-2+, and has a pth optimum of 5 [13].
  • METHODS: From genomic DNA all B-UGT encoding exons were amplified by polymerase chain reaction and sequenced to identify mutations causing CN II [2].

Chemical compound and disease context of nitridomethane

  • 4. In Ca2+-free solution, respiratory inhibition with hypoxia or CN (1 mM) only decreased [PCr], leaving [NTP] nearly unchanged [14].
  • The vibrations of the bound diatomic heme ligands CO, CN-, and NO are investigated by resonance Raman spectroscopy in various redox states of Escherichia coli sulfite reductase hemoprotein, and assignments are generated by use of isotopically labeled ligands [15].
  • The inductions of superoxide dismutase by Mn(II) or by Fe(II) were dioxygen dependent, but these metals did not affect the CN- -resistant respiration of E. coli B and did not influence the increase in the CN- -resistant respiration caused by paraquat [16].
  • The botulinal neurotoxin C1 gene is present on the CN phage but contains a stop mutation in the DNA region encoding the N-terminal part of the heavy chain (codon 553) [17].
  • Twenty minutes after injection of a formalin-killed active strain (CN6134, (CN6134, which inhibited tumour metastases) or a killed inactive strain (CN 5888, which did not inhibit metastases) the number of circulating blood platelets was reduced by 50% [18].

Biological context of nitridomethane

  • After 15 minutes of superfusion with glucose-free Tyrode's solution containing 1 mM CN-, action potential duration was reduced by 13 +/- 7% in endocardial cells and by 80 +/- 9% in epicardial cells (p less than 0.01) [19].
  • The insensitivity of Ca2+ homeostasis to CN- in more acid conditions implies that the Km (ATP) of the transport system is 100 microM or less [20].
  • In immature tracheary elements, the CN 8 epitope had a polarized localization pattern regardless of whether the cells are formed as parts of vessels in situ or as single tracheary elements in vitro, suggesting that cell polarity autonomously formed on the cell wall may function in tracheary element differentiation [21].
  • Studies with purified enzymes have shown that CN- also stimulates NADPH oxidation by horseradish peroxidase or lactoperoxidase, suggesting that the respiratory burst might be initiated by activation of a peroxidase-like enzyme in the human polymorphonuclear leukocyte [22].
  • The effects of NPSH on 4-NQO metabolism were studied by measuring 4-hydroxyaminoquinoline 1-oxide formation, CN- -insensitive oxygen consumption, and reduction of ferricytochromes c + c1 in normal cells and in cells pretreated with the thiol reagent N-ethylmaleimide [23].

Anatomical context of nitridomethane

  • Exposure of DiOC6(3)-loaded cytoplasts to fMet-Leu-Phe and PMA caused a rapid loss of dye fluorescence that was not inhibited by CN-, compatible with their lack of mitochondria [24].
  • One of the isolated mAbs, designated CN 8, recognized a cell wall component contained in the hemicellulosic fraction [21].
  • A homogenate of the toad urinary bladder epithelial cell layer has the two enzymatic activities unique to the glyoxylate cycle--isocitrate lyase (threo-Ds-isocitrate glyoxylate-lyase, EC and malate synthase [L-malate glyoxylate-lyase (CA-acetylating), EC]--as well as the capacity to carry out CN-insensitive palmitoyl-CoA oxidation [25].
  • Consistent with this, ethidium staining in dendrites was punctate, colocalized with mitochondria, and blocked by CN- [26].
  • Primary porcine aortic endothelial cells were seeded onto glass plates either noncoated (NC cells) or precoated with fibronectin (FN cells), laminin (LN cells), or collagen I (CN cells) [27].

Associations of nitridomethane with other chemical compounds

  • The increase in [Ca2+]c in the presence of CN- at pH 8.4 (50 nM.min-1) is compared with 45Ca2+ influx (0.62 mM.min-1) under the same conditions [20].
  • The mechanism of the CN- stimulation appears to involve an oxidatic chain reaction, since it stimulates markedly NADPH oxidation in the presence of an artificial superoxide-generating system [22].
  • At high concentrations of 13CN- the Cu(II) enzyme forms a 2:1 CN- complex with a shift to an axial ESR signal showing ligand nuclear superhyperfine structure from two magnetically equivalent equatorial nitrogen nuclei of the protein and two magnetically equivalent equatorial carbon ligands from two 13CN- anions [28].
  • Quantitative measurements indicate that HRP produces a 10-fold higher amount of CN- than LPO when incubated with SCN- and H2O2 [29].
  • The relationship between a novel NAD(P)H oxidase activity of ovoperoxidase and the CN- -resistant respiratory burst that follows fertilization of sea urchin eggs [30].

Gene context of nitridomethane

  • Neurectomy in these mutants results in a complete ipsilateral loss of Calb+ fibers in the cerebellar cortex, the CN and VN [31].
  • We have studied the interaction of ApoB with two lectin-like chaperones of the Endoplasmic Reticulum (ER)--Calnexin (CN) and Calreticulin (CR) [32].
  • Jaundice is common in ethnic Chinese infants, but to our knowledge Crigler-Najjar syndrome (CN syndrome) type I has never been reported in China. A Chinese girl with severe jaundice was recently diagnosed to have CN syndrome type I by analyzing the bilirubin-uridinediphospho (UDP)-glucuronosyltransferase gene (UGT1A1) [33].
  • The distal pocket of Fe(3+) hIDO was explored further by an exogenous heme ligand, CN(-); again, binding of L-Trp introduced strong H-bonding and/or steric interactions to the heme-bound CN(-) [34].
  • Total and CN-resistant superoxide dismutase (SOD) activities in MF of CC augmented following PTU challenge [35].

Analytical, diagnostic and therapeutic context of nitridomethane

  • We report here that application of the patch-clamp technique to CN-treated mammalian heart cells reveals specific K+ channels which are depressed by intracellular ATP (ATPi) at levels greater than 1 mM [36].
  • We now show that further purification of crude SGF by reverse-phase HPLC on muBondapak C18 and CN columns at pH 2 resolves it into two distinctly different polypeptides, which we call types alpha and beta transforming growth factors (TGFs) [37].
  • Cellular pH, however, plateaued at a higher level in the CN group (6.51 +/- 0.03) and IPC group (6.12 +/- 0.06) than in the control group (5.84 +/- 0.01, P < .001) [38].
  • Late changes in size and intensity were found for protein spots BA and CN, which decreased in size and intensity 5 hr after hepatectomy [39].
  • Fe-only hydrogenases, as well as their NiFe counterparts, display unusual intrinsic high-frequency IR bands that have been assigned to CO and CN(-) ligation to iron in their active sites [40].


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  5. -to: Hales CN, Ozanne SE (2003) for debate: fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013-1019. Plagemann, A., Rodekamp, E., Harder, T. Diabetologia (2004) [Pubmed]
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  14. Phosphorous compounds studied by 31P nuclear magnetic resonance spectroscopy in the taenia of guinea-pig caecum. Nakayama, S., Seo, Y., Takai, A., Tomita, T., Watari, H. J. Physiol. (Lond.) (1988) [Pubmed]
  15. Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. Han, S.H., Madden, J.F., Siegel, L.M., Spiro, T.G. Biochemistry (1989) [Pubmed]
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  30. The relationship between a novel NAD(P)H oxidase activity of ovoperoxidase and the CN- -resistant respiratory burst that follows fertilization of sea urchin eggs. Turner, E., Somers, C.E., Shapiro, B.M. J. Biol. Chem. (1985) [Pubmed]
  31. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. Bäurle, J., Vogten, H., Grüsser-Cornehls, U. J. Comp. Neurol. (1998) [Pubmed]
  32. Interaction of newly synthesized apolipoprotein B with calnexin and calreticulin requires glucose trimming in the endoplasmic reticulum. Tatu, U., Helenius, A. Biosci. Rep. (1999) [Pubmed]
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  34. The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions. Terentis, A.C., Thomas, S.R., Takikawa, O., Littlejohn, T.K., Truscott, R.J., Armstrong, R.S., Yeh, S.R., Stocker, R. J. Biol. Chem. (2002) [Pubmed]
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