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Van de Wiele, C. et al.

Christophe Van de Wiele, Philippe Phonteyne, Patrick Pauwels, Ingeborg Goethals, Rudi Van den Broecke, Veronique Cocquyt, Rudi Andre Dierckx,

Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry.

This study reports on the uptake of (99m)Tc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC). METHODS: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant bone-mestastasized breast carcinoma underwent (99m)Tc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive. RESULTS: The uptake of (99m)Tc-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. (99m)Tc-RP527 uptake was not found in any of the tamoxifen-resistant patients. CONCLUSION: Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.[1]

References

Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry. Van de Wiele, C., Phonteyne, P., Pauwels, P., Goethals, I., Van den Broecke, R., Cocquyt, V., Dierckx, R.A. J. Nucl. Med. (2008) [Pubmed]

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